复方嗜酸乳杆菌联合奥氮平治疗化疗致恶心呕吐疗效及对患者负性情绪的影响  

Efficacy of compound lactobacillus acidophilus combined with olanzapine in the treatment of chemotherapy-in⁃duced nausea and vomiting and its influence on patients’negative emotions

作　　者：刘雅娟[1] 丁玲玉 莫丽钦 张珍[1] LIU Yajuan;DING Lingyu;MO Liqin(Department of Internal Medicine,Hangzhou Cancer Hospital,Hangzhou 310002,China)

机构地区：[1]杭州市肿瘤医院内三科,310002

出　　处：《全科医学临床与教育》2022年第2期142-145,共4页Clinical Education of General Practice

摘　　要：目的观察复方嗜酸乳杆菌联合奥氮平治疗化疗致恶心呕吐疗效及对患者负性情绪的影响。方法选取实施化疗方案后恶心呕吐的恶性肿瘤患者80例,随机分为观察组和对照组,每组40例。对照组给予奥氮平+托烷司琼+地塞米松的止吐方案治疗,观察组在对照组止吐方案基础上给予复方嗜酸乳杆菌治疗。比较两组止吐总有效率和不良反应发生率,采用罗德恶心呕吐指数量表(INVR)评价恶心呕吐症状的严重程度,采用抑郁自评量表(SDS)和焦虑自评量表(SAS)评价负性情绪。结果治疗3 d后,观察组患者的止吐总有效率与对照组比较,差异无统计学意义(χ^(2)=1.92,P>0.05)。治疗后,两组患者的恶心评分(发生频率、恶心时间、严重程度)、呕吐评分(发生频率、呕吐量、严重程度)、干呕评分(发生频次、严重程度)、SDS评分、SAS评分低于治疗前,差异均有统计学意义(t分别=13.31、20.40、7.93、15.03、13.07、18.97、16.71、18.35、16.24、21.04、18.25、21.03、10.97、16.17、12.34、15.14、6.63、9.25、4.48、9.08,P均<0.05)。观察组治疗后的INVR评分、负性情绪评分低于对照组,差异均有统计学意义(t分别=8.15、6.78、8.73、3.78、6.21、4.55、7.14、4.13、5.05、5.10,P均<0.05)。观察组的便秘发生率和总不良反应低于对照组(χ^(2)分别=6.14、6.28,P均<0.05),嗜睡发生率与对照组比较,差异无统计学意义(χ^(2)=0.35,P>0.05)。结论复方嗜酸乳杆菌联合奥氮平治疗化疗致恶心呕吐的疗效较好,可缓解患者的不良情绪,降低便秘的发生。Objective To observe the efficacy of compound lactobacillus acidophilus combined with olanzapine in the treatment of chemotherapy-induced nausea and vomiting and its effect on patients'negative emotion.Methods A total of 80 patients with malignant tumors which chemotherapy induced nausea and vomiting were randomly divided into observa-tion group and control group,with 40 cases in each group.The control group was treated with olanzapine+tropisetron+dexamethasone antiemetic regimen,and the observation group was treated with compound lactobacillus acidophilus on the basis of the antiemetic regimen of the control group.The total effective rate and adverse reaction rate of the two groups were compared.The severity of nausea and vomiting symptoms were evaluated by Rhodes index of chemotherapy-induced nausea and vomiting(INVR),and the negative emotions were evaluated by self-rating depression scale(SDS)and self rating anxiety scale(SAS).Results There days after treatment,there was no significant difference in the total effective rate of antiemesis between the observation group and the control group(χ^(2)=1.92,P>0.05).After treatment,the nausea score(frequency,time and severity of nausea),vomiting score(frequency,vomit volume and severity of vomiting),retch-ing score(frequency and severity),SDS score and SAS score of the two groups were lower than those before treatment,the differences were statistically significant(t=13.31,20.40,7.93,15.03,13.07,18.97,16.71,18.35,16.24,21.04,18.25,21.03,10.97,16.17,12.34,15.14,6.63,9.25,4.48,9.08,P<0.05).The INVR score and negative emotion score of the ob-servation group after treatment were lower than those of the control group,and the differences were statisti-cally significant(t=8.15,6.78,8.73,3.78,6.21,4.55,7.14,4.13,5.05,5.10,P<0.05).The incidence of con-stipation and total adverse reactions in the observation group were lower than those in the control group(χ^(2)=6.14,6.28,P<0.05).There was no significant difference in the incidence of drowsiness between the observation group an

关 键 词：复方嗜酸乳杆菌 奥氮平 化疗 恶性肿瘤 恶心呕吐 负性情绪 

分 类 号：R730.53[医药卫生—肿瘤]