新疆塔城地区汉族和哈萨克族人群翼状胬肉患病率及危险因素研究  

The Prevalence and Risk Factors of Pterygium in Han and Kazak Ethnic Groups in Tacheng,Xinjiang

作　　者：李晓 李国庆[2] 徐静 汪京京 王林洪 何叶 Xiao Li;Guoqing Li;Jing Xu;Jingjing Wang;Linhong Wang;Ye He(Department of Ophthalmology,the Second Hospital of Tianjin Medical University,Tianjin 300211,China;Department of Ophthalmology,the Jiu Shi Hospital of Xinjiang Production and Construction Corps,Tacheng 834600,China;Ophthalmology of the Affiliated Hospital of North China University of Technology,Tangshan 063000,China;Tianjin Key Laboratory of Retinal Functions and Diseases,Tianjin Branch of National Clinical Research Center for Ocular Disease,Eye Institute and School of Optometry,Tianjin Medical University Eye Hospital,Tianjin 300384,China)

机构地区：[1]天津医科大学第二医院眼科,300211 [2]新疆生产建设兵团第九师医院眼科,塔城834600 [3]华北理工大学附属医院眼科,唐山063000 [4]天津医科大学眼科医院眼视光学院眼科研究所,国家眼耳鼻喉疾病临床医学研究中心天津市分中心,天津市视网膜功能与疾病重点实验室,300384

出　　处：《中华眼视光学与视觉科学杂志》2021年第12期903-909,共7页Chinese Journal Of Optometry Ophthalmology And Visual Science

基　　金：河北省研究生示范课程立项建设项目(KCJSZ2020055)。

摘　　要：目的:探讨新疆塔城地区汉族和哈萨克族50岁及以上人群翼状胬肉患病率及危险因素。方法:横断面研究。2015年10月至2018年6月由新疆生产建设兵团第九师医院对塔城地区50岁及以上人群翼状胬肉的患病率情况进行调查。按行政区域划分基本抽样单位(BSU),每个BSU约1000人,若BSU超过1500人则划分为2个以上的BSU。将该地区划分240个BSU,采用随机数表法抽选其中12个BSU进行调查。采用问卷调查的方式收集受检者的年龄、民族、性别、高血压、糖尿病、吸烟、年龄相关性白内障、冠心病、紫外线照射时间(夏)和紫外线照射时间(冬)等项目,采用裂隙灯显微镜观察受检者是否患有翼状胬肉,并对翼状胬肉的程度进行分级。采用秩和检验比较上述因素与翼状胬肉患病率之间的关系,对秩和检验中有统计学意义的因素行Logistic回归分析。结果:共计2114人纳入本次调查研究,其中489人(23.13%)患有翼状胬肉,50~59岁组有65人(21.04%);60~69岁组有168人(24.93%);70~79岁组有219人(23.08%);80岁以上人群中有37人(20.33%)。秩和检验显示不同性别(χ^(2)=5.560,P=0.018)、是否吸烟(χ^(2)=6.568,P=0.010)、不同紫外线照射时间(夏季)(χ^(2)=8.884,P<0.001)、是否患年龄相关性白内障(χ^(2)=4.397,P=0.036)、是否屈光不正(χ^(2)=8.273,P=0.004)在人群间患翼状胬肉中的比例有差异。Logistic多项回归分析显示紫外线照射(夏)[0—4时:OR=2.184,95%置信区间(CI):0.502-9.175;4—8时:OR=1.651,95%CI:1.256-3.295]、屈光不正(OR=1.903,95%CI:1.425-2.248)为该地区翼状胬肉患病的独立危险因素。结论:新疆塔城地区50岁及以上人群翼状胬肉患病率为23.13%,且汉族和哈萨克族不同民族间不具有差异性,紫外线照射(夏)是该地区翼状胬肉的危险因素。Objective:To investigate the prevalence and risk factors of pterygium in Han and Kazak ethnic groups aged 50 and older in the Tacheng region of Xinjiang.Methods:This was a cross-sectional study.The prevalence of pterygium in people aged 50 years and older in the Tacheng region was investigated and studied by the Jiu Shi Hospital of Xinjiang Production and Construction Corps from October 2015 to June 2018.The basic sampling units(BSU)were divided by administrative area,with approximately 1000 people in each BSU,or divided into more than 2 BSUs if the BSU exceeded 1500 people.The Tacheng region was divided into 240 BSUs.We randomly selected 12 BSUs by using random number table method.Questionnaires were used to collect information such as age,ethnicity,gender,hypertension,diabetes,smoking,age-related cataract,coronary heart disease,duration of UV exposure(summer),and duration of UV exposure(winter).Pterygium was diagnosed and graded clinically by slit-lamp examination.Rank sum test was performed to compare the association between the above factors and the prevalence of pterygium.Then,we entered all significant factors(predefined as P<0.05 in Rank sum test)into a multivariable logistic regression model to identify independent factors correlating with pterygium.Results:A total of 2114 individuals were included in this study,of which 489 were diagnosed with pterygium(23.13%),including 65(21.04%)in group aged 50-59,168(24.93%)in group aged 60-69,219(23.08%)in group aged 70-79,37(20.33%)in group aged above 80.Rank sum test showed that gender(F=5.560,P=0.018),smoking(F=6.568,P=0.010),duration of UV exposure(summer)(F=8.884,P<0.001),age-related cataract(F=4.397,P=0.036),and refractive error(F=8.273,P=0.004)were associated with pterygium.Further logistic multiple regression analysis revealed that UV exposure(summer)[0-4:OR=2.184,95%CI:0.502-9.175;4-8:OR=1.651,95%CI:1.256-3.295],and refractive error(OR=1.903,95%CI:1.425-2.248)were independent risk factors for the presence of pterygium in this region.Conclusions:The prevalen

关 键 词：翼状胬肉 患病率 危险因素 新疆塔城地区 

分 类 号：R77[医药卫生—眼科]