组织因子途径抑制物与妊娠相关疾病的研究现状  

Current situation of relationship between tissue factor pathway inhibitor and pregnancy-related diseases

作　　者：李冰[1] 徐婷婷[2] 朱丽丽 李宁[2] 徐爱群 张俊 李淑红 Li Bing;Xu Tingting;Zhu Lili;Li Ning;Xu Aiqun;Zhang Jun;Li Shuhong(Binzhou Medical University,Binzhou 264003,Shandong Province,China;Department of Obstetrics,Affiliated Yantai Yuhuangding Hospital of Qingdao University,Yantai 264099,Shandong Province,China;Department of Obstetrics,Yantai Affiliated Hospital of Binzhou Medical University,Yantai 264100,Shandong Province,China)

机构地区：[1]滨州医学院,山东264003 [2]青岛大学医学院附属烟台毓璜顶医院产科,山东烟台264099 [3]滨州医学院烟台附属医院产科,山东烟台264100

出　　处：《中华妇幼临床医学杂志（电子版）》2021年第6期650-656,共7页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：国家卫计委生育调控技术重点实验室项目(2018KF005);国家自然科学基金青年基金项目(81701453);烟台市科技计划项目(2020YD001)。

摘　　要：组织因子途径抑制物(TFPI)是人体血浆中的一种大分子质量蛋白质。人TFPI可被分为TFPI-1、-2亚型。人TFPI广泛表达于人体细胞中,参与机体凝血过程。目前研究发现,TFPI表达水平在心血管疾病,妊娠相关疾病,如子痫前期(PE),溶血、肝酶升高和低血小板计数(HELLP)综合征,羊水栓塞(AFE),血液病,脓毒症,以及肿瘤的发生、发展中起着重要作用。笔者拟就人TFPI的2种亚型的基本特征,人TFPI-1亚型及其分布、抑制机体凝血功能机制及其与妊娠相关疾病关系,以及人TFPI-2亚型分布、与妊娠相关疾病关系的最新研究现状进行阐述,旨在为人TFPI在妊娠相关疾病的诊断及基因治疗,提供新思路、新策略。Tissue factor pathway inhibitor(TFPI)is a high molecular weight protein in human plasma.TFPI is divided into TFPI-1 and TFPI-2 subtypes.TFPI is widely expressed in human cells and participates in the process of blood coagulation.Nowadays,studies have found that expression of TFPI plays an important role in the occurrence and development of heart disease,various pregnancy-related diseases,such as preeclampsia(PE),hemolysis,elevated liver enzymes,and low platelet(HELLP)syndrome,amniotic fluid embolism(AFE),hematopathy,sepsis,and tumor.The author intends to elaborate on basic characteristics of human TFPI-1 and TFPI-2 subtypes,distribution of human TFPI-1 subtype,mechanism of inhibiting blood coagulation,and its relationship with pregnancy-related diseases,and latest research status of distribution of human TFPI-2 subtype and its relationship with pregnancy-related diseases,in order to provide new ideas and strategies for diagnosis and gene therapy of TFPI in pregnancy-related diseases.

关 键 词：凝血致活酶 组织因子途径抑制物 人 妊娠并发症 分子靶向治疗 弥漫性血管内凝血 先兆子痫 栓塞 羊水 

分 类 号：R73[医药卫生—肿瘤]