Construction of Chiral All-Carbon Quaternary Stereocenters by Asymmetric Friedel-Crafts Reaction of Isatin Derivatives  

作　　者：Jindong Li Wenjing Lu Yangmian Lu Zhenggen Zha Zhiyong Wang 

机构地区：[1]Hefei National Laboratory for Physical Sciences at Microscale,Center for Excellence in Molecular Synthesis of Chinese Academy of Sciences,School of Chemistry and Materials Science in University of Science and Technology of China,Hefei,Anhui 230026,China

出　　处：《Chinese Journal of Chemistry》2022年第2期195-200,共6页中国化学（英文版）

摘　　要：Un der the catalysis of chiral Cu(ll)complex,C2 and C3 alkylati on of pyrrole and C3 alkylation of in dole were realized simulta neously.The chiral oxindole skeleton with an all-carb on quater nary stereogenic cen ter at the C3-position could be obtai ned exclusively with high yields(up to 95%)and excellent enantioselectivities(up to>99%).

关 键 词：Asymmetric synthesis CHEMOSELECTIVITY Enan tioselectivity Nucleophilic addition OXINDOLE 

分 类 号：O62[理学—有机化学]