Association of hypoxia-inducible factor-1α (HIF1α) 1772C/T genepolymorphism with susceptibility to renal cell carcinoma/prostatecancer  

作　　者：HONGYAN LI CHUNLING LIAO WENJUAN WENG HONGZHEN ZHONG TIANBIAO ZHOU 

机构地区：[1]Department of Nephrology,Huadu District People’s Hospital of Guangzhou,Southern Medical University,Guangzhou,China [2]Department of Nephrology,The Second Affiliated Hospital of Shantou University Medical College,Shantou,515041,China

出　　处：《BIOCELL》2020年第2期257-262,共6页生物细胞（英文）

基　　金：the Guangzhou Medical Key Discipline Construction Project(2017-2019);the Science and Technology Project of Shantou(Shanfuke(2019)106-4:190606165268433).

摘　　要：In this study,we used a meta-analysis method to evaluate the relationship between hypoxia-inducible factor-1α(HIF1α)1772C/T gene polymorphism(rs 11549465)and renal cell carcinoma(RCC)/prostate cancer risk.We searched for relevant studies(before March 1,2019)on Cochrane Library,Embase,and PubMed.Studies meeting the inclusion criteria were recruited into this meta-analysis.The outcome of dichotomous data was showed in the way of odds ratios(OR),and 95%confidence intervals(CI)were also counted.In this investigation,there was no association between HIF1α1772C/T gene polymorphism and susceptibility to RCC in Caucasians,Asians as well as overall populations.In addition,HIF1α1772C/T gene polymorphism was not found to be relevant to the survival in RCC.Interestingly,the T allele was relevant to prostate cancer risk in all populations,but not in Caucasians and Asians.However,the TT genotype and the CC genotype were not related to prostate cancer susceptibility in Asian,Caucasian,and all populations.In conclusion,the T allele of the HIF1α1772C/T gene polymorphism was related to prostate cancer risk in the overall populations.

关 键 词：Renal cell carcinoma (RCC) Prostate cancer Hypoxia-inducible factor-1α (HIF1α) 1772C/T gene polymorphism Meta-analysis 

分 类 号：R73[医药卫生—肿瘤]