Diverse Ring-seco Limonoids from Munronia unifoliolata and Their Biological Activities  

作　　者：Yunpeng Sun Qiurong Li Letian Cui Pengfei Tang Yongyi Li Lingyi Kong Jun Luo 

机构地区：[1]Jiangsu Key Laboratory of Bioactive Natural Product Research,State Key Laboratory of Natural Medicines,Department of Natural Medicinal Chemistry,China Pharmaceutical University,Nanjing,Jiangsu 210009,China

出　　处：《Chinese Journal of Chemistry》2022年第1期123-136,共14页中国化学（英文版）

基　　金：sponsored by the National Natural Science Foundation of China(31470416);the 111 Project from Ministry of Education of China;the State Administration of Foreign Export Affairs of China(B18056).

摘　　要：Twenty-two new limonoids,mufolinoids A—V(1—22),including six rings A,B-seco limonoids(1—6),twelve ring A-seco limonoids(7—18),four ring-intact limonoids(19—22),together with thirteen known compounds(23—35)were isolated from Munronia unifoliolata.Their structures including absolute configurations were elucidated by combination of NMR,HR-MS,single-crystal X-ray diffraction and calculations of ECD and NMR technologies.Compounds 24,25,33,34 could be significantly reversed the multidrug resistance of MCF-7/doxorubicin(DOX)cells,and the reversal fold(RF)was much higher than that of positive drug Verapamil.Compounds 24,28,and 29 exhibited significant anti-inflammatory activity with the IC50 values in the range of 17.7—39.4μmol/L.Furthermore,compound 29 could markedly inhibit the release of IL-1βby inhibiting the initiation and assembly of NLRP3 inflammasome,which demonstrates the great potential of limonoids as an anti-inflammatory agent.

关 键 词：Munronia unifoliolata LIMONOIDS Structure elucidation Inflammatory Natural products 

分 类 号：TQ28[化学工程—有机化工]