2型糖尿病和糖尿病肾病患者肠道菌群失衡模式及功能变化的研究  

Study on the imbalance pattern and functional changes of intestinal flora in patients with type 2 diabetes mellitus and diabetic kidney disease

作　　者：冯真真 钱磊[1] 赵琳[1] 霍剑锋 倪军[2] FENG Zhenzhen;QIAN Lei;ZHAO Lin;HUO Jianfeng;NI Jun(Department of Laboratory Medicine,Military Hospital of the Eighty-third Group of PLA,Xinxiang 453000,China;Department of Hematoendocrinology,Military Hospital of the Eighty-third Group of PLA,Xinxiang 453000,China)

机构地区：[1]中国人民解放军陆军第八十三集团军医院检验科,河南新乡453000 [2]中国人民解放军陆军第八十三集团军医院血液内分泌科,河南新乡453000

出　　处：《胃肠病学和肝病学杂志》2022年第2期203-207,共5页Chinese Journal of Gastroenterology and Hepatology

基　　金：河南省科技惠民计划(142207310004)。

摘　　要：目的研究和分析2型糖尿病(type 2 diabetes mellitus, T2DM)和糖尿病肾病(diabetic kidney disease, DKD)患者肠道菌群失衡模式,并观察肠道菌群功能变化。方法以随机数字法选取2018年9月至2019年10月我院收治的T2DM和DKD患者作为研究对象,并设定为T2DM组和DKD组,每组均纳入30例,同时选取健康体检者作为对照组,同样纳入30名,对三组的肠道菌群标志物进行对比和分析,同时对肠道菌群功能的变化进行总结。结果 (1)对照组与T2DM组、DKD组之间的肠道菌群多样性有显著性差异(P<0.05);(2)变化信号方面:T2DM组与DKD组变化存在大部分一致的情况(P<0.05),同时两组均出现了肠道菌群失衡模式,但T2DM以拟杆菌属增多为主要特点,DKD组则以乳杆菌属、史雷克菌属、厌氧棒状菌属和肠球菌属增多为主要特点;(3)T2DM组和DKD组患者肠道的功能变化存在一致性。结论 T2DM和DKD患者均存在特异性的肠道菌群失衡情况,其肠道功能变化无明显差异。Objective To study and analyze the imbalance pattern of intestinal flora in patients with type 2 diabetes mellitus(T2 DM) and diabetic kidney disease(DKD), and to observe the functional changes of intestinal flora.Methods Patients with T2 DM and DKD treated in our hospital from Sep. 2018 to Oct. 2019 were randomly selected as subjects, and were divided into T2 DM group and DKD group. 30 healthy subjects were selected as control group. The intestinal flora markers of the 3 groups were compared and analyzed, and the changes of intestinal flora function were summarized at the same time.Results(1) There were significant differences in intestinal microflora diversity in control group, T2 DM group and DKD group(P<0.05).(2) In terms of change signal, there were most of the same changes in T2 DM group and DKD group, and the imbalance pattern of intestinal flora appeared in both groups, but the increase of Bacteroides in T2 DM and Lactobacillus, Shrek, anaerobic Corynebacterium and Enterococcus in DKD group were the main characteristics.(3) There was consistency in the changes of intestinal function between T2 DM group and DKD group.Conclusion There is a specific imbalance of intestinal flora in patients with T2 DM and DKD, and there is no significant difference in intestinal function.

关 键 词：肠道菌群失衡 2型糖尿病 糖尿病肾病 

分 类 号：R57[医药卫生—消化系统]