蛋白酶激活受体在免疫炎症性疾病中的研究进展  

Research progress of protease activated receptors in immune inflammatory diseases

作　　者：宋佳[1] 李昕 张晓岚[1] SONG Jia;LI Xin;ZHANG Xiaolan(Department of Gastroenterology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第二医院消化内科,河北石家庄050000

出　　处：《胃肠病学和肝病学杂志》2022年第2期230-233,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：蛋白酶激活受体(protease activated receptors, PARs)是G蛋白偶联受体的一个亚家族,最早发现其与血栓形成、组织止血、癌症相关,随着研究的深入,发现PARs在感染、免疫炎症性疾病、纤维化疾病中发挥重要作用。目前已发现PARs有4种亚型,分别为PAR1~4,研究较多的为PAR1和PAR2,现就PAR1、PAR2在免疫炎症性疾病中的作用作一概述。Protease activated receptors(PARs), a subfamily of G-protein-coupled receptors, are first found to be associated with thrombosis, tissue hemostasis, and cancer. With the development of research, PARs are found to play an important role in infection, immune inflammatory diseases and fibrotic diseases. There are 4 subtypes of PARs, known as PAR1-4. Currently, PAR1 and PAR2 have been widely studied. The role of PAR1 and PAR2 in immune inflammatory diseases was reviewed.

关 键 词：蛋白酶激活受体 炎症 免疫 

分 类 号：R57[医药卫生—消化系统]