霉菌毒素对动物肠道功能的影响及其作用机制研究进展  

Research Progress of Effects of Mycotoxin on Intestinal Function and Its Mechanism

作　　者：陈豪 何流琴 刘娣 杨玲媛[1] CHEN Hao;HE Liuqin;LIU Ti;YANG Linyuan(College of Animal Science and Technology,Hunan Agricultural University,Changsha 410128,China;Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process,College of Life Science,Hunan Normal University,Changsha 410081,China;Institute of Animal Husbandry,Heilongjiang Academy of Agricultural Sciences,Harbin 150086,China)

机构地区：[1]湖南农业大学动物科学与技术学院,长沙410128 [2]湖南师范大学生命科学学院,动物肠道功能湖南省重点实验室,长沙410081 [3]黑龙江省农业科学院畜牧研究所,哈尔滨150086

出　　处：《动物营养学报》2022年第2期772-782,共11页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：中国科协青年托举人才项目(2019QNRC001);广西桂林市科技计划项目(2020010901);广西重点研发计划(桂科AB19259012);国家自然科学基金面上项目(31872370);湖湘高层次人才聚集工程项目(2018RS3111);湖南省动物肠道生态与健康国际科技创新合作基地开放基金项目。

摘　　要：霉菌毒素属于霉菌次级代谢产物,具有种类多、分布广、毒性大的特点。霉菌毒素作为畜牧业中的"隐形杀手",不仅严重降低了饲料品质,而且常存在于饲料原料中,影响动物机体健康,直接或间接造成食品安全问题。肠道作为消化吸收的主要场所,对霉菌毒素的刺激具有强烈的抵御和免疫作用,同时也深受霉菌毒素的损伤。玉米是主要的饲料原料之一,而黄曲霉毒素、脱氧雪腐镰刀菌烯醇和玉米赤霉烯酮是玉米中主要出现的霉菌毒素,因此了解这3种霉菌毒素的毒性机制显得尤为重要。本文综合国内外研究进展,主要以这3种霉菌毒素为例,就霉菌毒素对肠道屏障、免疫机能、抗氧化功能、微生态平衡和营养物质代谢等的影响及其作用机制研究进行综述,为降低饲料中霉菌毒素的危害和开发降解霉菌毒素产品提供新的思路和理论依据,同时也对提升我国畜禽肉品质和粮食战略安全具有重要意义。Mycotoxins are secondary metabolites of fungi,which are characterized by many kinds,wide distribution and high toxicity. Mycotoxins,as the“invisible killer”in animal husbandry,not only seriously reduce the quality of feed,but also often exist in feed materials,affecting animal health and directly or indirectly causing food safety problems. As the main place of digestion and absorption,intestinal tract has strong resistance and immunity to the stimulation of mycotoxins,and it is also deeply affected by mycotoxins. Maize is one of the main feed materials,and aflatoxin,deoxynivalenol and zearalenone are the main mycotoxins in maize,therefore,it is particularly important to understand the toxic mechanism of these three mycotoxins. In this paper,based on the research status at home and abroad,take these three mycotoxins as examples,the effects of mycotoxins on Intestinal barrier,immune function,antioxidant function,microecological balance and nutrient metabolism were reviewed,which provided new ideas and theoretical basis for reducing the harm of mycotoxins in feed and developing products for degrading mycotoxins. At the same time,it also has great significance to improve the quality of livestock and poultry meat and food strategic security in China.[Chinese Journal of Animal Nutrition,2022,34(2):772-782]

关 键 词：霉菌毒素 肠道菌群 免疫功能 氧化应激 营养代谢 

分 类 号：S816[农业科学—饲料科学]