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作 者:刘铭[1] 吴坤英[1] 郭宝芝[1] 宋芷霜[1] LIU Ming;WU Kunying;GUO Baozhi(Zhengzhou Maternal and Child Health Hospital,Zhengzhou,450000)
出 处:《实用癌症杂志》2022年第2期217-220,共4页The Practical Journal of Cancer
基 金:河南省科技攻关项目(编号:162102310091)。
摘 要:目的探讨血清miR-130b-5p和miR-142-5p在高危型人乳头瘤病毒(HPV)阳性的宫颈癌患者中的表达水平及其临床价值。方法选取高危型HPV阳性宫颈癌患者76例,另选取80例高危型HPV阳性非宫颈癌患者为对照组。采用ELISA法检测2组的血清miR-130b-5p和miR-142-5p表达水平以及分析其与宫颈癌发生的关系。结果高危型HPV阳性患者发生宫颈癌与年龄、是否绝经、有无分娩史、HPV分型无关(P均>0.05),宫颈癌患者血清miR-130b-5p和miR-142-5p表达水平显著高于对照组(P均<0.05)。多因素结果分析显示血清miR-130b-5p和miR-142-5p表达水平是影响高危型HPV阳性患者发生宫颈癌的独立危险因素(P<0.05)。血清miR-130b-5p和miR-142-5p水平评估宫颈癌诊断AUC分别为0.737,0.746,联合检测AUC为0.833。结论血清miR-130b-5p和miR-142-5p表达水平与宫颈癌的发生有关,可为宫颈癌的诊治提供数据参考。Objective To explore the expression level and clinical value of serum miR-130 b-5 p and miR-142-5 p in high-risk human papillomavirus(HPV) positive cervical cancer patients.Methods A total of 76 patients with high-risk HPV-positive cervical cancer were selected, and another 80 patients with high-risk HPV-positive non-cervical cancer were selected as the control group.ELISA method was used to detect the serum miR-130 b-5 p and miR-142-5 p expression levels in the 2 groups and analyze their relationship with the occurrence of cervical cancer.Results The occurrence of cervical cancer in high-risk HPV-positive patients has nothing to do with age, menopause, birth history, HPV type(all P>0.05),and serum miR-130 b-5 p and miR-142-5 p expression levels in cervical cancer patients were significantly higher than the control group(all P<0.05).Multivariate analysis showed that serum miR-130 b-5 p and miR-142-5 p expression levels were independent risk factors for cervical cancer in high-risk HPV-positive patients(P<0.05).Serum miR-130 b-5 p and miR-142-5 p levels assessed the predicted AUC of cervical cancer to be 0.737 and 0.746,respectively, and the combined detection AUC was 0.833.Conclusion The expression levels of serum miR-130 b-5 p and miR-142-5 p are related to the occurrence of cervical cancer, which can provide data reference for the diagnosis and treatment of cervical cancer.
关 键 词:高危型HPV MiR-130b-5p MiR-142-5p 宫颈癌
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