鼻咽癌患者适形调强放疗后头颈淋巴水肿的发生情况和相关因素  

Analysis of the Occurrence and Related Factors of Head and Neck Lymphedema After Adaptive Intensive Radiotherapy in Nasopharyngeal Carcinoma Patients

作　　者：王艳丹[1] 程楠[1] 史保院[1] 吴大鹏[1] WANG Yandan;CHENG Nan;SHI Baoyuan(Huaihe Hospital of Henan University,Kaifeng,475000)

机构地区：[1]河南大学淮河医院,475000

出　　处：《实用癌症杂志》2022年第2期247-249,共3页The Practical Journal of Cancer

基　　金：河南省重点科技攻关计划(编号:192102410112)。

摘　　要：目的分析鼻咽癌患者适形调强放疗后头颈淋巴水肿发生情况和相关因素。方法选取接受适形调强放疗后发生头颈淋巴水肿的63例鼻咽癌患者为发生组,并以1∶1配比选取同期适形调强放疗后未发生头颈淋巴水肿的63例鼻咽癌患者为未发生组。采用自制调查问卷收集2组性别、年龄、同步放化疗、诱导化疗、巩固化疗、放射性皮炎、临床分期等信息,分析鼻咽癌患者适形调强放疗后头颈淋巴水肿发生情况和相关因素分析。结果单因素分析显示放疗剂量、颈部淋巴结清扫、使用改善微循环药物与鼻咽癌患者适形调强放疗后发生头颈淋巴水肿有关(P<0.05);logistic回归分析显示,放疗剂量>60 Gy、采用颈部淋巴结清扫是鼻咽癌患者适形调强放疗后发生头颈淋巴水肿的危险因素,使用改善微循环药物是鼻咽癌患者适形调强放疗后发生头颈淋巴水肿的保护因素(P<0.05)。结论鼻咽癌患者适形调强放疗后发生头颈淋巴水肿的影响因素较多,临床应结合相关危险因素和保护因素,进行针对性防控,降低头颈淋巴水肿发生风险。Objective To analyze the occurrence of head and neck lymphlymphedema and related factors after conditioning radiotherapy in nasopharyngeal cancer.Methods 63 patients with head and neck lympheedema after HSRT were selected and 63 patients with head and neck lympheedema after the 1:1 ratio.Using gender, age, synchronous radiotherapy and chemotherapy, induction chemotherapy, consolidation chemotherapy, radioactive dermatitis, and clinical stage, the occurrence of head and neck lympheedema after conformal-adjusted intensive radiotherapy and related factors were analyzed.Results Univariate analysis showed that radiotherapy dose, neck lymph node dissection, and use of improved microcirculation drugs were associated with head and neck lympheedema after TRT(P<0.05);logistic regression analysis showed that radiotherapy dose> 60 Gy, was a risk factor after TRT in NPC patients, and improved microcirculation drugs was a protective factor after TRT in NPC patients(P<0.05).Conclusion Head and neck lymphoedema after conditioning radiotherapy, and combining relevant risk factors and protective factors should conduct targeted prevention and control to reduce the risk of head and neck lymphoedema.

关 键 词：鼻咽癌 适形调强放疗 头颈淋巴水肿 相关因素 

分 类 号：R739.63[医药卫生—肿瘤]