术前血清人附睾分泌蛋白4水平对早期宫颈鳞癌淋巴结转移的预测价值分析  

Predictive Value Analysis of Preoperative Human Epididymal Secretory Protein 4 Level in Early Cervical Squamous Cell Carcinoma Lymph Node Metastasis

作　　者：刘翠 李伟 胡宁霞 王大鑫 LIU Cui;LI Wei;HU Ningxia(The Third People's Hospital of Henan,Zhengzhou,450000)

机构地区：[1]河南省直第三人民医院,450000

出　　处：《实用癌症杂志》2022年第2期326-329,共4页The Practical Journal of Cancer

基　　金：河南省重点研发计划基金资助项目(编号:2019118077)。

摘　　要：目的探讨术前血清人附睾分泌蛋白4水平对早期宫颈鳞癌淋巴结转移的预测价值。方法选取早期宫颈鳞癌患者56例,分析术前血清人附睾分泌蛋白4水平与患者临床病理特征的关系及其对淋巴结转移的预测价值。结果患者术前血清HE4水平升高与FIGO分期、肿瘤直径>4 cm、间质浸润深度、LNM及LVSI有关(P均<0.05),与年龄、组织分化程度、宫旁浸润及阴道切缘受累无关(P均>0.05)。单因素分析显示,LNM与FIGO分期、肿瘤直径、间质浸润深度、HE4、LVSI、宫旁浸润有关(P均<0.05),而与年龄、阴道切缘是否受累组织、分化程度无相关性(P均>0.05),多因素结果分析显示:血清HE4及LVSI是影响早期宫颈鳞癌发生的独立危险因素(P<0.05)。血清LVSI、HE4水平评估脑膜瘤患者预后AUC分别为0.723、0.763,联合检测AUC为0.843。结论血清HE4可对术后早期宫颈鳞癌病情进行预测价值分析,为进一步研究早期宫颈鳞癌病情提供了数据参考。Objective To explore the predictive value of preoperative human epididymal secretory protein 4 levels in early cervical squamous cell carcinoma lymph node metastasis.Methods 56 patients with early cervical squamous cell carcinoma were selected.To analyze the relationship between the level of human epididymal secretory protein 4 before surgery and the clinical pathological characteristics of patients and its predictive value for lymph node metastasis.Results The preoperative increase of HE4 level was related to FIGO stage, tumor diameter>4 cm, interstitial invasion depth, LNM and LVSI(all P<0.05),but not related to age, degree of tissue differentiation, parauterine invasion and vaginal margin involvement(P all>0.05).Univariate analysis showed that LNM was related to FIGO stage, tumor diameter, depth of interstitial invasion, HE4,LVSI,and parauterine invasion(all P<0.05),but not related to age, degree of tissue differentiation, and whether vaginal margin was involved(all P>0.05),multivariate analysis showed that HE4 and LVSI were independent risk factors affecting the occurrence of early cervical squamous cell carcinoma(P<0.05).The prognostic AUCs of meningiomas assessed by LVSI and HE4 levels were 0.723 and 0.763 respectively, and the combined AUC was 0.843.Conclusion HE4 can analyze the predictive value of the early postoperative cervical squamous cell carcinoma, and provide a data reference for further research on the early cervical squamous cell carcinoma.

关 键 词：早期宫颈鳞癌 人附睾分泌蛋白4 淋巴结转移 预测 

分 类 号：R737.33[医药卫生—肿瘤]