重复经颅磁刺激联合帕罗西汀对老年重度抑郁症患者认知状态及生活能力的影响  被引量:7

Effects of repetitive transcranial magnetic stimulation combined with oral paroxetine on cognitive status and activities of daily living in older adult patients with severe depression

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作  者:胡燮军 甘建光 李松涛 Hu Xiejun;Gan Jianguang;Li Songtao(Second Department of Psychiatry,Shaoxing 7th People's Hospital,Shaoxing 312000,Zhejiang Province,China)

机构地区:[1]绍兴市第七人民医院精神二科,绍兴312000

出  处:《中国基层医药》2022年第2期161-164,共4页Chinese Journal of Primary Medicine and Pharmacy

基  金:浙江省医药卫生科技计划项目(2020ZH058)。

摘  要:目的探究重复经颅磁刺激(rTMS)联合帕罗西汀治疗老年重度抑郁症患者的疗效及对汉密尔顿抑郁量表(HAMD)评分、简易智能状态检查量表(MMSE)评分、日常生活能力量表(ADL)评分的影响。方法选取绍兴市第七人民医院2018年1月至2019年12月住院治疗的老年重度抑郁症患者192例,采用随机数字表法分为对照组、观察组各96例。对照组予口服帕罗西汀治疗,观察组予rTMS联合帕罗西汀治疗,两组均治疗1个月。比较两组临床疗效,治疗前后HAMD、MMSE、ADL评分以及不良事件发生率。结果观察组总有效率为96.88%(93/96),高于对照组的89.58%(86/96)(χ^(2)=4.04,P<0.05)。治疗后,观察组HAMD评分低于对照组[(6.43±2.33)分比(11.32±2.02)分,t=15.53,P<0.05],MMSE评分、ADL评分均高于对照组[(29.13±3.01)分、(71.52±5.32)分比(24.65±2.79)分、(69.65±5.17)分](t=10.69、2.47,均P<0.05)。两组患者治疗过程中不良事件发生率差异无统计学意义(P>0.05)。结论rTMS联合帕罗西汀治疗老年重度抑郁症患者的临床效果明显,可改善患者的认知功能,提高其自我生活能力。Objective To investigate the efficacy of repetitive transcranial magnetic stimulation(rTMS)combined with oral paroxetine in the treatment of older adult patients with severe depression and its effects on the scores of the Hamilton Rating Scale for Depression(HAMD),the Mini-Mental State Examination(MMSE),and Activities of Daily Living(ADL).Methods A total of 192 older adult patients with severe depression who received treatment in Shaoxing 7th People's Hospital from January 2018 to December 2019 were included in this study.They were randomly assigned to receive either oral paroxetine(control group,n=96)or rTMS+oral paroxetine(observation group,n=96).All patients received 1 month of treatment.Clinical efficacy was compared between the two groups.HAMD,MMSE,and ADL scores pre-and post-treatment and the incidence of adverse events during the treatment were compared between the two groups.Results Total response rate was significantly higher in the observation group than in the control group[96.88%(93/96)vs.89.58%(86/96),χ^(2)=4.04,P<0.05].HAMD scores post-treatment were significantly lower in the observation group than in the control group[(6.43±2.33)points vs.(11.32±2.02)points,t=15.53,P<0.05].MMSE and ADL scores post-treatment in the observation group were(29.13±3.01)points and(71.52±5.32)points,respectively,which were significantly higher than those in the control group[(24.65±2.79)points,(69.65±5.17)points,t=10.69,2.47,P<0.05].There was no significant difference in the incidence of adverse events between the two groups(P>0.05).Conclusion The combined therapy of rTMS and oral paroxetine is highly effective on severe depression in older adult patients.It can improve cognitive function and the activities of life living.

关 键 词:抑郁症 经颅磁刺激 汉密尔顿抑郁量表 简易智能状态检查量表 自我生活能力 治疗效果 帕罗西汀 

分 类 号:R749.4[医药卫生—神经病学与精神病学]

 

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