影响立体定向放射治疗原发性肝癌效果的相关因素分析  

Influential factors of stereotactic radiotherapy for primary liver cancer

作　　者：王如芹[1] 高振东 高宗毅[1] Wang Ruqin;Gao Zhendong;Gao Zongyi(Department of Radiotherapy,Binzhou Central Hospital,Binzhou 251700,Shandong Province,China;Equipment Department of Wudi County People's Hospital,Binzhou 251700,Shandong Province,China)

机构地区：[1]滨州市中心医院放疗科,滨州251700 [2]无棣县人民医院设备科,滨州251700

出　　处：《中国基层医药》2022年第2期285-290,共6页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨影响原发性肝癌动脉立体定向放射治疗效果的相关因素。方法收集2018年2月至2020年4月滨州市中心医院收治的行立体定向放射治疗的原发性肝癌患者116例的临床资料,分析影响原发性肝癌动脉立体定向放射治疗效果的相关因素。结果立体定向放射治疗总有效85例,总有效率为73.28%。不同临床资料患者肿瘤最大长径、动静脉瘘、门脉癌栓、远处转移、假包膜、肝功能分级(Child-Pugh分级)、巴塞罗那肝癌临床分期、立体定向放射治疗次数比较,差异均有统计学意义(χ^(2)=14.71、12.76、19.16、8.54、7.30、7.71、9.41、4.08,P<0.05或<0.01)。肿瘤最大长径、门脉癌栓、假包膜、Child-Pugh分级、巴塞罗那肝癌临床分期、立体定向放射治疗次数是影响原发性肝癌动脉立体定向放射治疗效果的独立危险因素(Waldχ^(2)=3.13、3.75、4.16、5.20、3.90、3.40,均P<0.05)。结论原发性肝癌患者动脉立体定向放射治疗效果的影响因素较多,早期明确高危因素,有利于最大限度降低立体定向放射治疗风险,提高立体定向放射治疗效果,改善预后。该研究有显著的创新性和科学性。Objective To investigate the factors affecting the therapeutic effects of stereotactic radiotherapy on primary liver cancer.Methods The clinical data of 116 patients with primary liver cancer who received stereotactic radiotherapy in Binzhou Central Hospital from February 2018 to April 2020 were retrospectively analyzed.The factors that affect the therapeutic effects of stereotactic radiotherapy on primary liver cancer were analyzed.Results Stereotactic radiotherapy was effective in 85 patients,with an overall response rate of 73.28%.There were no significant differences in maximum tumor diameter,arteriovenous fistula,portal vein tumor thrombus,distant metastasis,pseudocapsule,liver function Child-Pugh grade,Barcelona clinic liver cancer staging,and the number of stereotactic radiotherapies between different patients(χ^(2)=14.71,12.76,19.16,8.54,7.30,7.71,9.41,4.08,P<0.05 or<0.01).Maximum tumor diameter,portal vein tumor thrombus,pseudocapsule,liver function Child-Pugh grade,Barcelona clinic liver cancer staging,and the number of stereotactic radiotherapies were the independent risk factors that affect the therapeutic effects of stereotactic radiotherapy on primary liver cancer(Waldχ^(2)=3.13,3.75,4.16,5.20,3.90,3.40,all P<0.05).Conclusion Many factors affect the therapeutic effects of stereotactic radiotherapy on primary liver cancer.Early identification of the high-risk factors for primary liver cancer is conducive to minimizing the risk of stereotactic radiotherapy,improving the therapeutic effects of stereotactic radiotherapy,and improving the prognosis.This study is highly innovative and scientific.

关 键 词：肝癌 原发性 立体定向放射 影响因素 最大长径 门脉瘤栓 假包膜 CHILD-PUGH分级 巴塞罗那肝癌临床分期 效果 

分 类 号：R735.7[医药卫生—肿瘤]