山东省抑郁障碍患者睡眠质量的病例对照研究  

Sleep quality in patients with depressive disorder in Shandong province:A case-control study

作　　者：田一萍 张敬悬[2] 刘金同[2] 王汝展[2] 王延祜[2] 陈修哲[2] 米国琳[2] 陈旭[2] 程小菁[2] 王丽娜[2] 王灿[2] 胡丽丽[2] 郑世全 董兰[4] 王立刚[5] 陈莉 李武 刘燕花 朱君[9] 王艳梅 温庆华 李小鹏 张玉胜[13] 侯宗银 张秀茹 张廷侠[16] 郭素美 杨秀成 TIAN Yiping;ZHANG Jingxuan;LIU Jintong(Mental Health College, Jining Medical University, Jining 272067, China)

机构地区：[1]济宁医学院精神卫生学院,山东济宁272067 [2]山东省精神卫生中心 [3]临沂市精神卫生中心 [4]潍坊市精神卫生中心 [5]青岛市精神卫生中心 [6]菏泽市精神卫生中心 [7]山东省戴庄医院 [8]烟台市精神卫生中心 [9]济南市精神卫生中心 [10]聊城市精神卫生中心 [11]德州市精神卫生中心 [12]淄博市精神卫生中心 [13]滨州市人民医院 [14]枣庄市精神卫生中心 [15]威海市精神卫生中心 [16]日照市精神卫生中心 [17]东营市疾病预防控制中心 [18]济南市荣军医院

出　　处：《精神医学杂志》2021年第6期534-538,共5页Journal of Psychiatry

基　　金：山东省科技发展计划(编号:2014GSF118002)。

摘　　要：目的研究抑郁障碍患者(包括重性抑郁障碍与心境恶劣障碍两个亚型)睡眠质量的特点及相关影响因素。方法从2015年山东省18岁及以上人群精神障碍流行病学调查数据库筛查出940例抑郁障碍患者作为抑郁组,其中包括629例重性抑郁障碍患者及311例心境恶劣障碍患者,按同性别、同年龄组(相差±5岁)、同居住区域进行1∶1配对,选择940名健康人群作为对照组。使用一般健康问卷(GHQ-12)、匹兹堡睡眠质量指数(PSQI)、功能大体评定量表(GAF)和一般资料调查问卷对两组进行信息采集。结果抑郁组睡眠障碍的检出率为59.68%,对照组检出率为9.79%,两分组间检出率比较,差异有统计学意义(P<0.01)。抑郁组女性、年龄≥60岁、无业/失业、受教育年限0~6年、患有躯体疾病者的PSQI总分均高于其他分组(P<0.05)。在排除年龄等上述因素的影响下,抑郁组PSQI总分高于对照组(P<0.01)。不同首发年龄、社会功能损害程度、抑郁类别的抑郁障碍患者,PSQI总分比较差异有统计学意义(P<0.01)。对PSQI总分与患者首发年龄、GAF总分行进一步相关分析显示PSQI总分与首发年龄呈正相关(P<0.01),与GAF总分呈负相关(P<0.01)。结论抑郁障碍患者睡眠障碍检出率高于健康人群,且重性抑郁障碍患者睡眠质量比心境恶劣障碍患者更差。女性、年龄≥60岁、无业/失业、受教育年限0~6年、患有躯体疾病均为抑郁障碍患者睡眠质量的独立危险因素。首发年龄>60岁、重性抑郁障碍与社会功能损害严重为抑郁障碍患者睡眠质量的危险因素。Objective To explore the characteristics and influencing factors of sleep quality in patients with depressive disorder,including both major depressive disorder and dysthymic disorder subtypes.Methods A total of 940 patients with depressive disorder,including 629 patients with major depressive disorder and 311 patients with dysthymic disorder,were screened from the 2015 Shandong Province Epidemiological Survey of Mental Disorders in People Aged 18 Years and Older database,and all patients were paired 1∶1 with healthy controls(control group)according to the same gender,age group(difference±5 years),and area of residence(same village or street).Both groups were assessed with General Health Questionnaire(GHQ-12),Pittsburgh Sleep Quality Index(PSQI),Global Assessment Function(GAF),and self-designed general information questionnaire.Results The detection rates of sleep disorder in depression group and control group were 59.68%and 9.79%respectively,which showed significant difference between two groups(P<0.01).The total scores of PSQI in patients with depressive disorder of female,≥60 years old,jobless/unemployed,with 0~6 years of education,and suffering from somatic diseases were higher than those in other subgroups(P<0.05).Excluding the influence of the above factors such as age,the total score of PSQI in depression group was significantly higher than that in control group(P<0.01).There existed significant differences in the total scores of PSQI among depressive patients with different first-onset ages,social function impairment levels and depression subtypes(P<0.01).Correlation analysis showed that the total score of PSQI was positively correlated with the first-onset age,and negatively correlated with the total score of GAF(P<0.01).Conclusion The detection rate of sleep disorder in patients with depressive disorder is significantly higher than that of healthy controls,and the sleep quality of patients with major depressive disorder is worse than that of patients with dysthymic disorder.Female,age≥60 years old

关 键 词：抑郁障碍 睡眠质量 对照研究 流行病学调查 

分 类 号：R749.4[医药卫生—神经病学与精神病学]