不同年龄段人群甲状腺激素水平与抑郁症的关系  

Relationship Between Thyroid Hormone Levels and Depression in Different Age Groups

作　　者：李欣[1] 岑瑞香 杨惠英 苏慧珊 LI Xin;CEN Rui-xiang;YANG Hui-ying;SU Hui-shan(Department of Psychological Sleeping,Xiaolan People's Hospital,Zhongshan 528415,Guangdong,China)

机构地区：[1]中山市小榄人民医院心理睡眠科,广东中山528415

出　　处：《医学信息》2022年第4期98-101,共4页Journal of Medical Information

基　　金：中山市社科规划立项课题(编号:青202017)。

摘　　要：目的分析不同年龄段人群血清甲状腺激素水平与抑郁症的关系。方法选取2018年5月-2021年5月中山市小榄人民医院门诊收治的90例抑郁症患者作为观察组,另选取同期我院90例健康人群作为对照组,比较两组不同年龄亚组(年龄<60岁为中青年亚组,≥60岁为老年亚组)游离三碘甲腺原氨酸(FT3)、血清游离甲状腺素(FT4)、三碘甲状腺激素(T3),四碘甲状腺激素(T4)、促甲状腺激素(TSH)水平,采用Pearson相关分析甲状腺激素与HAMD评分的关系,并采用多因素Logistic回归分析影响不同年龄段抑郁症病情程度的因素。结果 (1)观察组中老年亚组T3水平低于对照组,中青年亚组T3、FT4水平低于对照组,差异有统计学差异(P<0.05);(2)观察组中老年亚组焦虑/躯体化、睡眠评分以及HAMD总分高于中青年亚组,差异有统计学意义(P<0.05);Pearson相关性分析显示,观察组老年亚组T3水平与阻滞因子呈正相关(P<0.05);FT4水平与焦虑/躯体化、HAMD总分呈正相关,与阻滞因子呈负相关(P<0.05);TSH水平与焦虑/躯体化呈正相关(P<0.05);中青年亚组T3水平与焦虑/躯体化呈正相关(P<0.05);(3)多因素Logistic回归分析显示,中青年人群中血清FT4水平是影响抑郁症病情程度的因素(P<0.05);老年人群中血清TSH水平是影响抑郁症病情程度的因素(P<0.05)。结论不同年龄阶段甲状腺激素水平与抑郁症患者相关性不同,中青年抑郁症患者病情严重程度与甲状腺激素水平的相关性较低,老年抑郁症患者随着T3、FT4水平下降,抑郁症病情愈加严重。Objective To analyze the relationship between thyroid hormone levels and depression in different age groups.Methods A total of 90 patients with depression admitted to Xiaolan People ’s Hospital of Zhongshan from May 2018 to May 2021 were selected as observation group,and 90 healthy people in our hospital during the same period were selected as control group.Serum free triiodothyronine(FT3),free tetraiodothyronine(FT4)three iodine thyroid homone(T3),four iodine thyroid homone(T4),and thyrotropin(TSH) were compared between the two groups at different ages(age<60 years old as the young and middle-aged subgroup,age ≥60 years old as the elderly subgroup).The clinical symptoms of the patients in the observation group were analyzed by(Hamilton depression scale,HAMD) score of Hamilton Depression scale,and the correlation between thyroid hormone level and depression was analyzed by logistic linear regression.Pearson correlation analysis was used to analyze the relationship between thyroid hormone and HAMD score,and multivariate Logistic regression analysis was used to analyze the factors affecting the severity of depression in different age groups.Results(1)The T3 level of elderly subgroup in the observation group was lower than that in the control group,and the T3 and FT4 levels of young and middle-aged subgroup were lower than those in the control group,the difference was statistically significant( P <0.05).(2)The anxiety/somatization,sleep score and HAMD total score of the elderly subgroup in the observation group were higher than those in the young and middle-aged subgroup,and the difference was statistically significant(P<0.05).Pearson correlation analysis showed that the T3 level of the elderly subgroup in the observation group was positively correlated with the blocking factor(P <0.05);FT4 level was positively correlated with anxiety/somatization,HAMD total score,and negatively correlated with blocking factor(P<0.05);TSH level was positively correlated with anxiety/somatization(P<0.05);T3 level was positively c

关 键 词：甲状腺激素 抑郁症 三碘甲状腺原氨酸 促甲状腺激素 

分 类 号：R749[医药卫生—神经病学与精神病学]