结构脂肪乳对食管胃结合部肿瘤患者免疫功能与营养状态的影响  

Effect of Structured Fat Emulsion on Immune Function and Nutritional Status in Patients with Esophagogastric Junction Tumor

作　　者：邹庆伟 陈小龙 冯立波 刘庆 夏冬 ZOU Qing-wei;CHEN Xiao-long;FENG Li-bo;LIU Qing;XIA Dong(Department of General Surgery,Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan,China)

机构地区：[1]西南医科大学附属医院普外科,四川泸州646000

出　　处：《医学信息》2022年第4期150-152,共3页Journal of Medical Information

基　　金：四川省教育厅资助项目(编号:16ZA0197)。

摘　　要：目的探讨结构脂肪乳对食管胃结合部肿瘤患者免疫功能与营养状态的影响。方法选取2019年1月-2021年1月我院收治的64例食管胃结合部肿瘤患者作为研究对象,按照随机数字表法分为对照组和观察组,每组32例。对照组给予脂肪乳注射液(C14~24)进行常规肠外营养支持,观察组给予结构脂肪乳注射液(C6~24)进行常规肠外营养支持,比较两组治疗前后细胞免疫指标(CD3^(+)、CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+))、体液免疫指标(Ig A、Ig G及Ig M)与营养指标(PA、ALB、TRF、RBP)。结果观察组治疗后CD8^(+)低于对照组,CD3^(+)、CD4^(+)与CD4^(+)/CD8^(+)高于对照组(P<0.05);观察组Ig A、Ig G及Ig M、PA、ALB、TRF及RBP均高于对照组(P<0.05)。结论结构脂肪乳注射液可有效改善食管胃结合部肿瘤患者的免疫功能与营养状态。Objective To investigate the effect of structured fat emulsion on immune function and nutritional status in patients with esophagogastric junction tumors.Methods A total of 64 patients with gastroesophageal junction tumors admitted to our hospital from January 2019 to January 2021 were selected as subjects.They were divided into control group and observation group according to random number table method,32 cases in each group.The control group was given fat emulsion injection (C14-24) for routine parenteral nutrition support,and the observation group was given structural fat emulsion injection (C6-24) for routine parenteral nutrition support.The cellular immune indexes (CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)),humoral immune indexes (Ig A,Ig G and Ig M) and nutritional indexes (PA,ALB,TRF,RBP) before and after treatment were compared between the two groups.Results After treatment,CD8^(+)in the observation group was lower than that in the control group,CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)were higher than those in the control group (P<0.05).Ig A,Ig G and Ig M,PA,ALB,TRF and RBP in the observation group were higher than those in the control group (P<0.05).Conclusion Structural fat emulsion injection can effectively improve the immune function and nutritional status of patients with gastroesophageal junction tumors.

关 键 词：结构脂肪乳 食管胃结合部肿瘤 肠外营养支持 

分 类 号：R735[医药卫生—肿瘤]