乳腺浸润性导管癌患者血清miR-10b水平变化及其与临床病理特征的关系分析  

Changes of serum miR-10b level in patients with invasive ductal carcinoma of the breast and its correlation with clinicopathological characteristics

作　　者：孙铁 王英姿[1] 李立[1] SUN Tie;WANG Ying-zi;LI Li(Third Department of General Surgery,Liaoning Provincial People’s Hospital,Shenyang 110016,China)

机构地区：[1]辽宁省人民医院普外三科,110016

出　　处：《中国实用医药》2022年第4期8-10,共3页China Practical Medicine

摘　　要：目的探究乳腺浸润性导管癌患者血清microRNA-10b(miR-10b)水平变化及其水平表达与临床病理特征的关系。方法选取82例乳腺浸润性导管癌患者作为实验组,另选取82例行健康检查的健康女性作为对照组。检测并比较两组血清miR-10b水平,分析实验组患者miR-10b水平与人类表皮生长因子受体2(HER-2)、肿瘤直径、临床分期、年龄、月经状态、淋巴结转移情况、孕激素受体(PR)、雌激素受体(ER)等临床病理特征的关系。结果实验组患者miR-10b表达水平(6.53±1.61)高于对照组的(2.23±0.62),差异具有统计学意义(P<0.05)。实验组HER-2阳性、肿瘤直径>2 cm、临床分期Ⅲ~Ⅳ期、有淋巴结转移患者血清miR-10b表达水平显著高于HER-2阴性、肿瘤直径≤2 cm、临床分期Ⅰ期和Ⅱ期、无淋巴结转移患者,差异有统计学意义(P<0.05);实验组不同年龄(>50岁、≤50岁)、PR和ER状态(阳性、阴性)及月经状态(绝经、未绝经)患者血清miR-10b表达水平比较,差异无统计学意义(P>0.05)。结论乳腺浸润性导管癌患者体内血清mi R-10b表达水平显著增加,且mi R-10b对乳腺浸润性导管癌患者的诊断以及预后预测有一定的价值,其与乳腺癌的侵袭、转移等生物学行为密切相关。Objective To investigate the changes of serum microRNA-10 b(miR-10 b) level in patients with invasive ductal carcinoma of the breast and its correlation with clinicopathological characteristics.Methods A total of 82 patients with invasive ductal carcinoma of the breast were selected as the experimental group,and 82 healthy women who underwent health examinationsduring the same period were selected as the control group.The serum miR-10 b expression levels of the two groups were compared.The correlation between miR-10 b levels and clinicopathological characteristics of human epidermal growth factor receptor 2(HER-2),tumor diameter,clinical stage,age,menstrual status,lymph node metastasis,progesterone receptor(PR),estrogen receptor(ER) in the experimental group was analyzed.Results The miR-10 b expression level(6.53±1.61) in the experimental group was higher than(2.23±0.62) of the control group,and the difference was statistically significant(P<0.05).In the experimental group,the serum miR-10 b expression levels of patients with HER-2 positive,tumor diameter >2 cm,clinical stage Ⅲ-Ⅳ and lymph node metastasis were significantly higher than those of patients with HER-2 negative,tumor diameter ≤2 cm,clinical stage ⅠandⅡ and no lymph node metastasis,and the difference was statistically significant(P<0.05).In the experimental group,the differences in serum miR-10 b expression levels were not statistically significant(P>0.05) when comparing patients of different ages(>50 years,≤50 years),PR and ER status(positive,negative) and menstrual status(menopausal,non-menopausal).Conclusion The level of serum miR-10 b increases significantly in patients with invasive ductal carcinoma of the breast,and miR-10 b expression level has certain value in the diagnosis and prognosis of patients with invasive ductal carcinoma of the breast.It is closely related to the biological behavior of breast cancer invasion and metastasis.

关 键 词：乳腺浸润性导管癌 microRNA-10b 临床病理特征 

分 类 号：R737.9[医药卫生—肿瘤]