中医综合治疗对肺癌治疗相关癌性疲乏的影响  

Influence of comprehensive treatment of traditional Chinese medicine on cancer-related fatigue related to lung cancer treatment

作　　者：陈学芬 谭翔文 陈正[3] 李和根[4] 马恰怡 孙建立[4] 周蕾[4] CHEN Xuefen;TAN Xiangwen;CHEN Zheng;LI Hegen;MA Qiayi;SUN Jianli;ZHOU Lei(College of Public Health,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Changning Tianshan Hospital of Traditional Chinese Medicine,Shanghai,200051,China;School of Basic Medical Sciences,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学公共健康学院,上海201203 [2]上海市长宁区天山中医医院,上海200051 [3]上海中医药大学基础医学院,上海201203 [4]上海中医药大学附属龙华医院,上海200032

出　　处：《现代中西医结合杂志》2022年第3期293-298,319,共7页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：上海市卫生和计划生育委员会中医药科研专项课题(2016LP052);上海市进一步加快中医药事业发展三年行动计划(2018-2020年)中医专科培育项目建设(中医肿瘤专科);长宁区卫生健康委员会医学重点(特色)专科计划项目(20191004);上海市长宁区天山中医医院PI团队建设项目。

摘　　要：目的采用简易疲乏量表中国版(BFI-C)、肺癌症状分级量化表评测中医综合治疗对肺癌治疗相关癌性疲乏的影响。方法使用前瞻、随机、对照的成组设计研究,将2015年4月—2018年12月在上海市长宁区天山中医医院肿瘤科住院的125例肺癌经手术、化疗、放疗后出现治疗相关癌性疲乏肺脾气虚证患者随机分为2组,对照组给予复方苦参注射液联合参麦注射液静滴,试验组在对照组治疗基础上联合中医适宜技术(耳穴、敷贴、隔姜灸)治疗,2组干预措施均以10d为1次,每月干预1次,共干预2次。分别于第1次干预前、第2次干预前、第2次干预后20d对2组患者进行BFI-C和肺癌症状分级量化表评测,比较2组肺癌不同治疗方式患者各项评分;观察2组患者干预前及第2次干预后血白细胞计数、中性粒细胞绝对值变化,统计2组干预2次后症状疗效。结果2组中肺癌不同治疗方式患者BFI-C中疲乏程度均分、疲乏影响均分经混合效应模型分析显示组别与时间交互作用均有统计学意义(P均<0.001);试验组手术患者疲乏程度均分、放疗患者疲乏影响均分在第2次干预前与对照组第1次干预前比较差异均无统计学意义(P>0.05),第2次干预后第20天均明显低于对照组第1次干预前(P均<0.05);试验组化疗患者第2次干预前和第2次干预后第20天疲乏程度均分、疲乏影响均分均明显低于对照组第1次干预前(P均<0.05)。2组中手术患者中医症状积分经混合效应模型分析显示组别与时间交互项无统计学意义(P>0.05),化疗、放疗患者组别与时间交互项均有统计学意义(P均<0.05);试验组化疗患者第2次干预前、第2次干预后第20天中医症状积分均较对照组第1次干预前明显降低(P均<0.05);试验组放疗患者第2次干预前中医症状积分与对照组第1次干预前比较差异无统计学意义(P>0.05),第2次干预后第20天较对照组第1次干预前明显降低(P<0.05)�Objective It is to evaluate the effect of Traditional Chinese Medicine(TCM)comprehensive treatment on lung cancer treatment-related cancer fatigue by the Brief fatigue inventory-Chinese version(BFI-C)and the Lung Cancer Symptom Grading Quantitative Scale.Methods According to a prospective,randomized,controlled grouping method,125 patients with treatment-related cancer fatigue of type of lung and spleen Qi deficiency after surgery,chemotherapy and radiotherapy for lung cancer who were hospitalized in the Department of Oncology,Changning District Tianshan Hospital of Traditional Chinese Medicine from April 2015 to December 2018 were randomly divided into two groups.The control group was given compound Kushen injection combined with Shenmai injection by intravenous drip,and the experimental group was treated with appropriate TCM therapy(auricular acupuncture,application,ginger-partitioned moxibustion)on the basis of the treatment of the control group.10 days as one intervention,one intervention per month,2 interventions in total.Before the first intervention and the second intervention,and 20 days after the second intervention,the patients in the two groups were evaluated by BFI-C and the Quantitative Scale of Lung Cancer Symptom Grading,and the scores of the patients in the two groups treated with different treatment methods were compared.The changes of blood white blood cell count and absolute value of neutrophils before the intervention and after the second intervention were compared,and the symptomatic efficacy of the two groups after the second intervention was evaluated.Results In the two groups,the average score of fatigue degree and the average score of fatigue effect in BFI-C of patients treated with different treatment methods of lung cancer showed that the interaction between group and time was statistically significant according to mixed effects model analysis(P<0.001).There was no significant difference in the average score of fatigue degree and the average score of fatigue impact of radiotherapy patien

关 键 词：中医适宜技术 中医综合治疗 肺癌 治疗相关癌性疲乏 简易疲乏量表 肺癌症状分级量化表 

分 类 号：R734.2[医药卫生—肿瘤]