骨疏康颗粒口服联合[牙合]垫治疗颞下颌关节紊乱病疗效观察  

Observation on curative effect of oral administration of Gushukang granule combined with occlusal plate on temporomandibular joint disorder

作　　者：俞婷婷 陈静 章燕珍[3] 朱旌[4] YU Tingting;CHEN Jing;ZHANG Yanzhen;ZHU Jing(Ningbo Huamei Hospital,University of Chinese Academy of Sciences,Ningbo 315177,Zhejiang;Hangzhou Traditional Chinese Medicine Hospital,Hangzhou 310000,Zhejiang;The Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310000;Hangzhou First People’s Hospital,Zhejiang Hangzhou 310000)

机构地区：[1]中国科学院大学宁波华美医院,浙江宁波315177 [2]杭州市中医院,浙江杭州310000 [3]浙江大学医学院附属第二医院,浙江杭州310000 [4]杭州市第一人民医院,浙江杭州310000

出　　处：《现代中西医结合杂志》2022年第3期338-342,347,共6页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：浙江省自然科学基金项目(Y20H140015);浙江省中医药科技计划项目(2019ZB097)。

摘　　要：目的观察骨疏康颗粒口服联合[牙合]垫治疗颞下颌关节紊乱病(TMD)的临床疗效。方法收集2019年9月—2020年12月在浙江大学医学院附属第二医院综合牙科就诊的TMD患者70例,随机分为2组,试验组35例予骨疏康颗粒口服联合[牙合]垫治疗,对照组35例予单纯[牙合]垫治疗。观察比较2组患者治疗前、治疗第5周及治疗结束后的关节区疼痛情况、无痛最大张口度及MRI分级改善情况。结果试验过程中有6例患者因失访剔除,最终试验组31例、对照组33例完成研究。与治疗前相比,2组治疗第5周时及治疗结束后的疼痛程度均明显减轻(P均<0.05),张口度显著增大(P均<0.05)。与治疗第5周时相比,2组治疗结束后的疼痛程度均明显减轻(P均<0.05),张口度显著增大(P均<0.05)。治疗第5周时,试验组疼痛程度明显轻于对照组(P<0.05),张口度显著大于对照组(P<0.05)。治疗结束后,试验组疼痛程度明显轻于对照组(P<0.05),2组张口度比较差异无统计学意义(P>0.05)。治疗第5周,试验组MRI分级为2级者疼痛程度轻于对照组(P<0.05),张口度变化值与对照组比较差异无统计学意义(P>0.05);试验组MRI分级为3级者疼痛程度轻于对照组(P<0.05),张口度变化值显著大于对照组(P<0.05)。治疗第5周,试验组急性患者疼痛程度轻于对照组(P<0.05),张口度变化值与对照组比较差异无统计学意义(P>0.05);试验组慢性患者疼痛程度轻于对照组(P<0.05),张口度变化值显著大于对照组(P<0.05)。结论骨疏康颗粒口服联合[牙合]垫治疗能有效改善TMD患者关节区疼痛及张口受限情况。Objective It is to observe the clinical efficacy of oral administration of Gushukang granules combined with occlusal plate in the treatment of temporomandibular disorders(TMD). Methods A total of 70 patients with TMD who visited the General Dentistry of the Second Affiliated Hospital of School of Medicine of Zhejiang University from September 2019 to December 2020 were collected and randomly divided into 2 groups. 35 cases in the experimental group were treated with oral administration of Gushukang granules combined with occlusal plate, and 35 cases in the control group were treated with simple occlusal plate. The pain in the joint area, the maximum painless mouth opening and the improvement of MRI grading were observed and compared between the two groups before treatment, at the 5 th week of treatment and after treatment. Results During the trial, 6 patients were excluded due to loss to follow-up. Finally, 31 patients in the experimental group and 33 patients in the control group completed the study. Compared with before treatment, the pain degree at the 5 th week of treatment and after treatment in both groups was significantly reduced(P<0.05), and the mouth opening was significantly increased(P<0.05). Compared with the 5 th week of treatment, the pain degree after treatment in both groups was significantly reduced(P<0.05), and the mouth opening was significantly increased(P<0.05). At the 5 th week of treatment, the pain degree of the experimental group was significantly lighter than that of the control group(P<0.05), and the mouth opening degree was significantly greater than that of the control group(P<0.05). After treatment, the pain degree in the experimental group was significantly lighter than that in the control group(P<0.05), and there was no significant difference in the mouth opening degree between the two groups(P>0.05). At the 5 th week of treatment, the pain degree of the patients with MRI grade 2 in the experimental group was lighter than that in the control group(P<0.05), and there was no signifi

关 键 词：颞下颌关节紊乱病 骨疏康颗粒 [牙合]垫 

分 类 号：R782.6[医药卫生—口腔医学]