致心脏毒性中药的减毒及防治心脏毒性中药的研究进展  

Detoxification of cardiotoxic traditional Chinese medicine and traditional Chinese medicine for prevention of cardiotoxicity:a review

作　　者：王栋 黄凯 郭淑贞 WANG Dong;HUANG Kai;GUO Shu-zhen(School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 102488,China)

机构地区：[1]北京中医药大学中医学院,北京102488

出　　处：《中国中药杂志》2022年第1期18-23,共6页China Journal of Chinese Materia Medica

基　　金：北京中医药大学高层次人才启动项目。

摘　　要：心脏毒性是药物临床应用的主要安全性问题之一。近年来,随着对中医药研究的重视与深入,关于对中药心脏安全性的评价与防治心脏毒性反应的研究日益增多,且研究方向集中在致心脏毒性中药的安全使用或靶向心脏的中药毒性成分的发现。关于中药心脏安全性评价的研究方法,该综述介绍了中药心脏安全性评价的临床指标、细胞与动物模型研究进展。关于提升中药心脏安全性的研究,该文回顾总结了常见致心脏毒性中药的毒性物质基础和作用机制,以及通过控制毒性物质含量、改变给药剂型、合理炮制、配伍等方式降低心脏毒性的研究。关于防治心脏毒性的方药与有效成分,该文归纳了近年来防治化疗药物诱导心脏毒性反应的方药及中药有效成分及其作用机制,以期对中药的心脏安全性评价与临床合理应用提供参考。Cardiotoxicity is smong the main safety problems of drugs in clinical application.In recent years,traditional Chinese medicine has been gradually emphasized and studies on the evaluation of cardiac safety and prevention of cardiotoxicity of Chinese medicine have been on the rise,particularly the cardiotoxic Chinese medicine or the Chinese medicine components targeting cardiotoxicity.As for the research methods for cardiac safety evaluation of Chinese medicine,this review introduces the related clinical indexes and cell and animal models.As to the improvement of heart safety,this study reviews the material basis and mechanism of cardiotoxic Chinese medicines as well as the alleviation of cardiotoxicity by controlling the content of toxic compounds and changing dosage form,processing method,and compatibility of Chinese medicine.In addition,the effective components and mechanisms of prescriptions and active compounds in Chinese medicine for preventing and treating cardiotoxicity induced by chemotherapeutic drugs in recent years were summarized.This review is expected to serve as a reference for cardiac safety evaluation and clinical rational application of Chinese medicine.

关 键 词：中药 心脏安全性 临床研究 细胞与动物模型 

分 类 号：R285[医药卫生—中药学]