Developmental hemostasis in the neonatal period  

作　　者：Vicente Rey y Formoso Ricardo Barreto Mota Henrique Soares 

机构地区：[1]Neonatology Department(Reference Center for Congenital Heart Diseases),São João University Hospital Center,Alameda Prof.Hernâni Monteiro,4200-319,Porto,Portugal [2]Faculty of Medicine,Porto University,Porto,Portugal

出　　处：《World Journal of Pediatrics》2022年第1期7-15,共9页世界儿科杂志（英文版）

摘　　要：Background The hemostatic system is complex and evolves continuously since gestation and well into the adult years,in a process known as“developmental hemostasis.”Data sources A comprehensive review was performed after an extensive literature search on PubMed/MEDLINE concerning developmental hemostasis during the neonatal period.Relevant cross references were also included.Results Although part of a system,each component of the hemostatic system evolves differently,with many displaying both quantitative and qualitative age-related differences.This leads to drastic disparities between the coagulation system of neonates and both other children’s and adults’,while still maintaining a generally balanced and physiological hemostasis.The motives behind this process remain to be fully elucidated but may be,at least in part,related to non-hemostatic factors.Conclusions Knowledge regarding“developmental hemostasis”is essential for everyone caring for newborns or even children in general and in this review,we describe each hemostatic system component’s neonatal characteristics and age-related progression as well as explore some of the possible physiological motives behind the process.

关 键 词：Coagulation factors Developmental hemostasis HEMOSTASIS NEWBORN PLATELETS 

分 类 号：R722.1[医药卫生—儿科]