腹腔镜结直肠癌根治术对患者血清肿瘤标志物及肠胃功能的影响  

Effect of Laparoscopic Radical Resection of Colorectal Cancer on Serum Tumor Markers and Gastrointestinal Function in Patients

作　　者：郭晓磊[1] 杨战锋[1] 傅聿铭[1] 闫军浩 吴万庆[1] GUO Xiaolei;YANG Zhanfeng;FU Yuming;YAN Junhao;WU Wanqing(Department of Gastroinestinal and Thyroid Surgery,the Fifth Afiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第五附属医院胃肠甲状腺外科,河南郑州450000

出　　处：《河南医学研究》2022年第3期447-451,共5页Henan Medical Research

摘　　要：目的观察腹腔镜结直肠癌根治术对结直肠癌患者血清肿瘤标志物及肠胃功能的影响。方法选择2018年10月至2020年10月于郑州大学第五附属医院就诊的86例结直肠癌患者,根据随机数字表法分组,43例患者为研究组,接受腹腔镜结直肠癌根治术,43例患者为参照组,接受传统开腹结直肠癌根治术。术前、术后3d检测两组皮质醇(Cor)、6-酮前列腺素E1α(6-keto-PGE1α)、血管活性肠肽(VIP)、促胃液素-17(G-17)、Ghrelin、超氧化物歧化酶(SOD)、丙二醛(MDA)、糖类抗原(CA)242、癌胚抗原(CEA)水平,记录两组术中出血量、住院时间、肠鸣音恢复时间,比较两组并发症情况。结果研究组患者Cor、6-keto-PGE1α、MDA水平均低于参照组(P<0.05),研究组SOD水平高于参照组(P<0.05),研究组VIP、G-17、Ghrelin水平高于参照组(P<0.05),研究组CEA、CA242水平低于参照组(P<0.05),研究组术中出血量少于参照组(P<0.05),研究组住院、肠鸣音恢复时间短于参照组(P<0.05),研究组患者并发症发生率(4.65%)较参照组(23.26%)低(P<0.05)。结论腹腔镜结直肠癌根治术治疗结直肠癌患者,可降低应激反应及疼痛递质水平,促进胃肠功能恢复,降低肿瘤标志物水平,减少并发症,促进患者康复。Objective To observe the effect of laparoscopic radical resection of colorectal cancer on serum tumor markers and gastrointestinal function in patients with colorectal cancer.Methods Eighty-six patients with colorectal cancer who were treated in the Fifth Affiliated Hospital of Zhengzhou University between October 2018 and October 2020 were selected and grouped according to the random number table method.Forty-three patients were the study group,and received laparoscopie radical resection of colorectal cancer.Forty-three patients were the reference group,and received traditional open radical resection of colorectal cancer.Cortisol(Cor),6-keto-prostaglandin E1a(6-keto-PGE1a),vasoactive intestinal peptide(VIP),gastrin-17(G-17),Ghrelin,superoxide dismutase(SOD),malondialdehyde(MDA)、carbohydrate antigen(CA)242 and carcinoembryonic antigen(CEA)levels were tested before and 3 days after the operation.Intraoperative blood loss,hospitalization,and bowel sound recovery time were recorded between the two groups,and the complications of the two groups were compared.Results The levels of Cor,6-keto-PGE1a,and MDA in the study group were lower than those in the reference group(P<0.05),and the SOD levels in the study group were higher than those in the reference group(P<0.05).The levelsof VIP,G-17 and Ghrelin in the study group were higher than the reference group(P<0.05).The CEA and CA242 levels in the study group were lower than the reference group(P<0.05).The intraoperative blood loss in the study group was less than the reference group(P<0.05).The time of hospitalized and bowel sounds recovered in study group were shorter than that of the reference group(P<0.05),and the incidence of complications in the study group(4.65%)was lower than that in the reference group(23.26%)(P<0.05).Conclusion Laparoscopic radical resection of colorectal cancer for patients with colorectal cancer can reduce stress response and pain mediator levels,promote gast rointestinal function recovery,reduce tumor marker levels,reduce complications,and

关 键 词：腹腔镜 结直肠癌根治术 氧化应激 疼痛递质 胃肠功能 肿瘤标志物 并发症 

分 类 号：R735.3[医药卫生—肿瘤]