银杏叶提取物联合rt-PA静脉溶栓治疗急性脑梗死的效果  

Effect of Ginkgo Biloba Extract Combined with Rt-PA Intravenous Thrombolysis in the Treatment of A cute Cerebral Infarction

作　　者：王辉[1] 刘玉培 杨瑞莲 WANG Hui;LIU Yupei;YANG Ruilian(Four wrds of Neurology,Nanyang Central Hospital,Nanyang 473000,China;Department of Nephrology,rheumatism and Immunology,Nanyang Central Hospital,Nanyang 473000,China)

机构地区：[1]南阳市中心医院神经内科四病区,河南南阳473000 [2]南阳市中心医院肾病风湿免疫科,河南南阳473000

出　　处：《河南医学研究》2022年第3期524-527,共4页Henan Medical Research

摘　　要：目的探讨急性脑梗死(ACI)患者采用重组组织型纤溶酶原激活剂(rt-PA)静脉溶栓联合银杏叶提取物治疗的效果。方法选取2019年1月至2021年1月南阳市中心医院收治的86例ACI患者为研究对象,依据随机数字表法分为两组,各48例。在常规治疗基础上,对照组接受rt-PA静脉溶栓治疗,观察组在对照组基础上联合银杏叶提取物治疗,两组连续治疗7d。比较两组患者治疗7d的临床效果;于治疗前、治疗7d,比较两组血液流变学相关指标(纤维蛋白原、血浆粘度)、血清细胞因子[血清单核细胞趋化蛋白-1(MCP-1)、血清组织蛋白酶S(Cats)、血小板反应蛋白-1(TSP-1)]水平及治疗期间的不良反应发生情况。结果治疗7d,观察组总有效率较对照组高(P<0.05);治疗7d,两组血清MCP-1、Cats及TSP-1水平低于治疗前,观察组较对照组低(P<0.05);治疗7d,两组纤维蛋白原、血浆粘度水平低于治疗前,观察组低于对照(P<0.05);两组治疗期间均未发生不良反应。结论rt-PA静脉溶栓与银杏叶提取物联合治疗ACI可提高患者临床效果,改善血液流变学,减轻炎症反应,且不增加不良反应的发生。Objective To investigate the effect of intravenous thrombolysis of Ginkgo biloba extract combined with recombi nant tissue plasminogen activator(t-PA)in the treatment of patients with acute cerebral infarction(ACI).Methods A total of 86 patients with ACI treated in Nanyang Central Hospital from January 2019 to January 2021 were selected as the research objects.According to the random number table method,they were divided into control group and observation group,with 48 cases in each group.Both groups received routine treatment,on this basis,the control group was treated with rt-PA intravenous thrombolysis,and the observation group was treated with Ginkgo biloba extract combined with rt-PA intravenous thrombolysis,both groups were treated continuously for 7 days.The clinical effect of patients in the two groups after 7 days of treatment was compared.Before treatment and 7 days after treatment,the hemortheological indexes(fibrinogen,plasma viscosity),serum cytokines[serum cathepsin S(Cats),platelet reactive protein-1(TSP-1),serum monocyte chemoattractant protein-1(MCP-1)]and the occurrence of adverse reactions during treatment were compared between the two groups.Results After 7 days of treatment,the total effective rate in the observation group was higher than that in the control group(P<0.05).Afer 7 days of treatment,the levels of serum Cats,TSP-1 and MCP-1 in both groups were lower than those before treatment,and the observation group was lower in comparison with the control group(P<0.05).After 7 days of treatment,the levels of fibrinogen and plasma viscosity in both groups were lower than those before treatment,and the observation group was lower in compari son with the control group(P<0.05).During the treatment,no adverse reactions occurred in both groups.Conclusion Ginkgo biloba extract combined with rt-PA intravenous thrombolysis in the treatment of ACI can improve the clinical symptoms and hemorheology,reduce the inflammatory reaction of patients,and will not increase the adverse reactions.

关 键 词：急性脑梗死 银杏叶提取物 重组组织型纤溶酶原激活剂 血液流变学 

分 类 号：R743.33[医药卫生—神经病学与精神病学]