补骨脂-肉豆蔻药对现代研究进展  

Progress of Modern Research on Buguzhi(Psoraleae Fructus)-Roudoukou(Myristicae Semen)

作　　者：曲晓琳 张婧茜 殷佳[2] 傅春升[2] QU Xiaolin;ZHANG Jingxi;YIN Jia;FU Chunsheng(College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Department of Pharmacy,The Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学药学院,山东济南250355 [2]山东中医药大学附属医院药学部,山东济南250014

出　　处：《山东中医杂志》2022年第3期348-353,共6页Shandong Journal of Traditional Chinese Medicine

基　　金：山东省中医药科技发展计划项目(编号:2019-0079)。

摘　　要：补骨脂-肉豆蔻是临床常用温补脾肾药对,组方名二神丸,是四神丸的核心组成。现代学者主要着眼化学成分、药理作用、临床应用、提取工艺等方面对其进行研究。两种药物配伍后能够增加有效成分的溶出,产生新物质,但目前对配伍比例以及新物质的研究较少;其临床应用和药理作用的相关研究主要集中在消化系统疾病,如通过减轻炎症反应、减缓胃肠蠕动、减轻内脏疼痛、调节肠道菌群等机制治疗肠易激综合征、溃疡性结肠炎、慢性腹泻、慢性结肠炎等,对于其他系统疾病的研究报道较少;提取工艺方面,关于该药对最佳提取工艺的研究较少,主要集中在醇提工艺和水提工艺的研究。参考文献55篇。Buguzhi(Psoraleae Fructus)-Roudoukou(Myristicae Semen)is a common medicinal pair in clinic for warming and nourishing spleen and kidney,known as Sishen Pill(四神丸),and is the core ingredients of Ershen Pill(二神丸).Modern scholars mainly focus on its chemical composition,pharmacological effects,clinical application,extraction technology and other aspects to study it.The combination of the these two medicinals can increase the dissolution of the active ingredients and generate new substances,but there are few studies on the combination ratio and new substances.Research on its clinical application and pharmacological effects mainly focuses on digestive system diseases,for example,reducing inflammatory reactions,reducing gastrointestinal motility,reducing visceral pain,regulating intestinal flora and other mechanisms to treat irritable bowel syndrome,ulcera-tive colitis,chronic diarrhea and chronic colitis,with few reports on other systemic diseases.On extraction technology,there are few researches on the optimal extraction process of the medicinals.Current research mainly involves alcohol extraction process and water extraction process.There are 55 papers cited in the references.

关 键 词：补骨脂 肉豆蔻 药对 温补脾肾 二神丸 四神丸 消化系统疾病 提取工艺 

分 类 号：R282.71[医药卫生—中药学]