基于AFQ技术的CAE患儿脑白质纤维完整性改变的研究  

Study on the changes of white matter fiber integrity in children with CAE based on AFQ

作　　者：余传勇[1] 邱文超 孙锦涛 高媛 王小姗[1] YU Chuanyong;QIU Wenchao;SUN Jintao;GAO Yuan;WANG Xiaoshan(Department of Neurology,the Affiliated Brain Hospital of Nanjing Medical University,Nanjing 210029;'Department of Neurology,Huai'an Second People's Hospital,Huai'an 223300,China)

机构地区：[1]南京医科大学附属脑科医院神经内科,江苏南京210029 [2]淮安市第二人民医院神经内科,江苏淮安223300

出　　处：《南京医科大学学报（自然科学版）》2021年第12期1767-1773,共7页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金面上项目(82071455);江苏省卫生计生委科研课题面上项目(H2018062);南京市科技局医疗卫生国际联合研发项目(201911044)。

摘　　要：目的:通过分析儿童失神癫痫(childhood absence epilepsy,CAE)患儿脑白质纤维完整性的改变,以探讨CAE患儿认知损害的可能靶点。方法:选取2011年11月—2020年11月在南京市儿童院或南京脑科医院就诊的29例CAE患儿[男11例,女18例,平均年龄(8.4±1.9)岁]和年龄、性别相匹配的24例健康儿童[男9例,女15例,平均年龄(7.9±1.4)岁]使用德国西门子3.0T MRI仪采集所有被试的DTI及T1数据,通过AFQ软件提取出脑内20条白质纤维束,提取出每条纤维束100个等分节点上的各向异性分数(fractional anisotropy,FA)值及平均扩散率(mean diffusivity,MD)值,定量比较其差异。统计方法采用独立样本t检验及多重比较校正。结果:CAE患儿在大部分纤维束节点中可出现FA值下降及MD值升高,其中在弓形束及钩状束的改变最为明显。结论:CAE患儿存在脑内白质纤维束完整性的改变,且以弓形束及钩状束损伤为著,提示CAE患儿认知损害的靶点可能在弓形束及钩状束。Objective:This study aims to explore the possible targets of cognitive impairment in children with childhood absence epilepsy(CAE)by analyzing the changes of white matter fiber integrity in children with CAE.Methods:From November 2011 to November 2020,there were 29 children with CAE,11 males and 18 females,with an average age of 8.4±1.9 years,from Nanjing Children’s Hospital or Nanjing Brain Hospital;and 24 healthy children were matched in age and sex,9 males and 15 females,with an average age of 7.9±1.4 years old.The DTI and T1 data of all subjects were collected by Siemens 3.0 T MRI.Twenty white matter fiber bundles were extracted by AFQ,and the fractional anisotropy(FA)and mean diffusivity(MD)values on 100 equal sub-nodes of each fiber bundle were extracted.The differences between CAE group and control group in each node were compared.The statistical methods were independent sample t-test and multiple comparison correction.Result:The FA decreased and MD increased in most fiber bundle nodes of CAE children,especially in uncinate and arcuate.Conclusion:The study suggests that there is a change of white matter fiber bundle integrity in children with CAE,especially in uncinate and arcuate.The damage of uncinate and arcuate is the main targets of cognitive impairment in CAE.

关 键 词：纤维束自动定量法 儿童失神癫痫 扩散张量成像 钩状束 弓形束 

分 类 号：R742.1[医药卫生—神经病学与精神病学]