NF-КBp65在鼻咽癌组织的表达及临床病理意义  

The expression and clinicopathological significance of NF-КBp65 in nasopharyngeal carcinoma

作　　者：周梅 姬文莉[2] 周小军[3] 禤瑞霞[1] 陈钰伟 王书芹[1] ZHOU Mei;JI Wenli;ZHOU Xiaojun;XUN Ruixia;CHEN Yuwei;WANG Shuqing(Departerment of Pathology,Traditional Chinese Medical Hospital,Zhongshan 528400,China)

机构地区：[1]广东省中山市中医院病理科,528400 [2]新疆医科大学附属肿瘤医院病理科,乌鲁木齐 [3]广东省中山市中医院科教科

出　　处：《中国中西医结合耳鼻咽喉科杂志》2022年第1期1-5,共5页Chinese Journal of Otorhinolaryngology in Integrative Medicine

基　　金：广东中山市社会公益科技研究项目(编号:2018B1055)。

摘　　要：目的探讨NF-КBp65蛋白和mRNA在鼻咽癌组织中的表达及其临床病理意义。方法运用免疫组化和RT-PCR的方法检测NF-КBp65蛋白和mRNA在60例鼻咽癌和30例鼻咽炎组织中的表达,分析鼻咽癌组织NF-ΚBp65表达活性差异与鼻咽癌患者临床病理指标的相关性。结果鼻咽癌组织中NF-КBp65蛋白和mRNA的表达明显高于鼻咽炎组织(P<0.05);鼻咽癌组织中NF-КBp65蛋白和mRNA的表达与肿瘤大小、淋巴结转移及临床分期有显著相关性(P<0.05);肿瘤体积越大、有淋巴结转移、临床分期越高的鼻咽癌NF-КBp65蛋白和mRNA的表达越高。结论NNF-КBp65表达高的鼻咽癌可能更具有侵袭性,预后更差。NF-КBp65在鼻咽癌发生发展过程中可能发挥着重要作用,是鼻咽癌患者独立的预后因子。Objective To investigate the expression and clinicopathological significance of NF-КBp65 protein and mRNA in nasopharyngeal carcinoma.Methods The expressions of NF-КBp65 protein and mRNA in 60 cases of nasopharyngeal carcinoma and 30 cases of nasopharyngitis tissues were detected by immunohistochemistry and RT-PCR,to analyze the correlation between the expression of NF-КBp65 and clinicopathological parameters in nasopharyngeal carcinoma.Results The expression level of NF-КBp65 protein and mRNA in nasopharyngeal carcinoma tissue were significantly higher than that in nasopharyngitis tissue(P<0.05);the expression of NF-КBp65 protein and mRNA in nasopharyngeal carcinoma tissue was significantly correlated with tumor size,lymph node metastasis,and clinical stage(P<0.05);the expression of NF-КBp65 protein and mRNA was higher in nasopharyngeal carcinoma with larger tumor size,lymph node metastasis and higher clinical stage.Conclusion Nasopharyngeal carcinoma with high expression of NF-КBp65 may be more invasive and have worse prognosis.NF-КBp65 may play an important role in the occurrence and development of nasopharyngeal carcinoma,and is an independent prognostic factor of nasopharyngeal carcinoma patients.

关 键 词：NF-КBp65 鼻咽癌 免疫组化 RT-PCR 

分 类 号：R739.63[医药卫生—肿瘤]