^(18)F标记的PSMA PET/CT对前列腺癌区域淋巴结转移诊断价值的Meta分析  

Diagnostic Value of ^(18)F-labeled PSMA PET/CT for Regional Lymph Node Metastasis in Prostate Cancer:A Meta-analysis

作　　者：曾春媛 程勇[1] 徐浩[1] ZENG Chunyuan;CHENG Yong;XU Hao(Department of Nuclear Medicine,The First Affiliated Hospital of Ji'nan University,Guangzhou 510630,China)

机构地区：[1]暨南大学附属第一医院核医学科,广州510630

出　　处：《肿瘤防治研究》2022年第2期141-147,共7页Cancer Research on Prevention and Treatment

摘　　要：目的系统评价^(18)F标记的PSMA PET/CT对前列腺癌区域淋巴结转移的诊断价值。方法检索2000年1月1日至2021年5月31日PubMed、Embase、Cochrane Library、Web of Science、中国知网(CNKI)、维普、万方数据库中应用^(18)F标记的PSMA PET/CT诊断前列腺癌区域淋巴结转移和分期的研究。两名研究者独立筛选文献、提取数据及评价文献质量。使用Meta-disc1.4和Stata16.0软件对数据进行Meta分析。结果共纳入8篇文献,包括754例前列腺癌患者的2101枚淋巴结。Meta分析显示,合并敏感度、合并特异性、合并阳性似然比、合并阴性似然比及诊断比值比分别为0.82(95%CI:0.61~0.93)、0.98(95%CI:0.91~1.00)、45.7(95%CI:9.0~231.3)、0.18(95%CI:0.07~0.45)、251(95%CI:34~1851)。综合受试者工作特征曲线下面积为0.97(95%CI:0.95~0.98)。结论^(18)F标记的PSMA PET/CT对前列腺癌区域淋巴结转移具有较高的诊断价值。Objective To evaluate the diagnostic value of^(18)F-labeled PSMA PET/CT for regional lymph node metastasis in prostate cancer.Methods We searched PubMed,Embase,Cochrane Library,Web of Science,CNKI,VIP and Wanfang database from January 1,2000 to May 31,2021 for the studies about the diagnosis of^(18)F-labeled PSMA PET/CT for regional lymph node metastasis and staging in prostate cancer.Two investigators screened literature,extracted relevant data and assessed the quality of the literature independently.The meta-analysis was performed using Meta-disc 1.4 and Stata 16.0 software.Results A total of 8 studies were finally included for the analysis,consisting of 754 prostate cancer patients and 2101 lymph nodes.The results of this meta-analysis showed pooled sensitivity,pooled specificity,pooled positive likelihood ratio,pooled negative likelihood ratio and diagnostic ratio were 0.82 (95%CI:0.61-0.93),0.98 (95%CI:0.91-1.00),45.7 (95%CI:9.0-231.3),0.18 (95%CI:0.07-0.45) and 251 (95%CI:34-1851),respectively.The area under the SROC curve was 0.97 (95%CI:0.95-0.98).Conclusion^(18)F-labeled PSMA PET/CT has a high diagnostic value for regional lymph node metastasis in prostate cancer.

关 键 词：^(18)F PSMA PET/CT 前列腺癌 淋巴结 META分析 

分 类 号：R737.25[医药卫生—肿瘤]