播散肿瘤细胞的休眠与存活机制及其在防治实体瘤转移中的作用  

Dormancy and Survival Mechanism of Disseminated Tumor Cell and Its Role in Prevention and Treatment of Solid Tumor Metastasis

作　　者：阙祖俊 席志超[3,4] 徐宏喜 田建辉[1,2] QUE Zujun;XI Zhichao;XU Hongxi;TIAN Jianhui(Clinical Oncology Center,Shanghai Municipal Hospital of TCM,Shanghai University of TCM,Shanghai 200071,China;Institute of Traditional Chinese Medicine Oncology,Longhua Hospital,Shanghai University of TCM,Shanghai 200032,China;School of Pharmacy,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属市中医医院肿瘤临床医学中心,上海200071 [2]上海中医药大学附属龙华医院中医肿瘤研究所,上海200032 [3]上海中医药大学中药学院,上海201203 [4]中药创新药物研发上海高校工程研究中心,上海201203

出　　处：《肿瘤防治研究》2022年第2期154-158,共5页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金(82174017,82174245);上海市青年科技英才扬帆计划(20YF1449900)。

摘　　要：肿瘤转移的防治可显著改善实体瘤患者的生存,然而目前临床上仍缺乏有效的转移防治药物,其根本原因是现有的干预措施和治疗药物都难以实现对转移的精准防治。由于早期术后患者的转移靶器官中早已存在播散肿瘤细胞(DTCs),这些DTCs难以用现有的影像学技术进行检测,也缺乏有效的干预药物和疗效评估体系,而DTCs一旦生长至影像学可检测时患者即已属于癌症晚期,这成为了制约转移防治突破的瓶颈。本文将对DTCs在转移靶器官中休眠与存活机制及其干预策略进行综述,以期改善转移防治疗效。The prevention and treatment of tumor metastasis can significantly improve the survival of patients with solid tumors.However,there is still a lack of effective drugs for the prevention and treatment of metastasis.The main reason is that the existing intervention and therapeutic drugs are difficult to achieve precise prevention and treatment of metastasis.Due to disseminated tumor cells (DTCs) already exist in the metastatic target organs of early postoperative patients,they are difficult to be detected with existing imaging techniques,and there is a lack of effective intervention drugs and efficacy evaluation systems.When DTCs grow to be detectable by imaging,the patient is already in the advanced stage of cancer,which has become a bottleneck restricting the breakthroughs in metastasis prevention and treatment.This paper reviews the dormancy and survival mechanism of DTCs in metastatic target organs and its intervention strategies,in order to promote the curative effect of metastasis prevention and treatment.

关 键 词：肿瘤 播散肿瘤细胞 转移 肿瘤休眠 实体瘤 

分 类 号：R73-3[医药卫生—肿瘤] R730.1[医药卫生—临床医学]