转化生长因子-β1、可溶性CD105、CC趋化因子配体20水平与三阴性乳腺癌患者术后复发的关系  

Levels of transforming growth factor-β1,soluble C105,CC chemokine ligand 20 and their relationship with postoperative recurrence in triple-negative breast cancer patients

作　　者：马鹏飞[1] 田霞[1] 寇建锋[1] MA Pengfei;TIAN Xia;KOU Jianfeng(Department of Cardiothoracic and Breast Surgery,Yan’an People’s Hospital,Yan’an 716000,Shaanxi,China)

机构地区：[1]延安市人民医院心胸乳腺外科,陕西延安7160000

出　　处：《癌症进展》2022年第1期29-33,共5页Oncology Progress

摘　　要：目的探讨转化生长因子-β1(TGF-β1)、可溶性CD105(s-CD105)、CC趋化因子配体20(CCL20)水平与三阴性乳腺癌患者术后复发的关系。方法共纳入90例三阴性乳腺癌患者,依据术后6个月复发情况分为复发组(n=19)和未复发组(n=71),依据年龄匹配原则选取同期40例健康者为对照组。比较3组受试者血清TGF-β1、s-CD105、CCL20水平,三阴性乳腺癌患者术后复发的影响因素采用多因素Logistic回归分析;绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),评估血清TGF-β1、s-CD105、CCL20单独及联合检测对三阴性乳腺癌患者术后复发的预测价值。结果复发组和未复发组患者血清TGF-β1、s-CD105、CCL20水平均明显高于对照组(P﹤0.01),且复发组患者血清TGF-β1、s-CD105、CCL20水平均明显高于未复发组(P﹤0.01)。多因素Logistic回归分析结果显示,年龄﹥50岁、TNM分期为Ⅲ~Ⅳ期、病理类型为浸润性导管癌、术前淋巴结转移、术后未辅助治疗、TGF-β1过表达、s-CD105过表达、CCL20过表达均是三阴性乳腺癌患者术后复发的独立危险因素(P﹤0.05)。ROC曲线显示,血清TGF-β1、s-CD105、CCL20联合检测预测三阴性乳腺癌患者术后复发的AUC为0.879,均高于三者单独检测,此时灵敏度、特异度分别为84.21%、91.55%。结论血清TGF-β1、s-CD105、CCL20水平与三阴性乳腺癌患者的术后复发风险密切相关,可作为预测三阴性乳腺癌患者术后复发的有效指标。Objective To investigate the levels of transforming growth factor-β1(TGF-β1),soluble CD105(s-CD105),and CC chemokine ligand 20(CCL20)and their relationship with postoperative recurrence in triple-negative breast cancer patients.Method A total of 90 patients with triple-negative breast cancer were enrolled,and all subjects were divided into a recurrence group(n=19)and a non-recurrence group(n=71)according to the recurrence inside 6 months after surgery.40 healthy subjects were selected as the control group according to the age-matching principle.The serum levels of TGF-β1,s-CD105,and CCL20 were compared among the three groups,and the risk factors of postoperative recurrence in triple-negative breast cancer patients were analyzed by multivariate Logistic regression.Besides,the receiver operating characteristic(ROC)curve was drawn,and area under the curve(AUC)was calculated.The value was used to evaluate the predictive value of serum TGF-β1,s-CD105,and CCL20 for postoperative recurrence in triple-negative breast cancer patients.Result The levels of serum TGF-β1,s-CD105,and CCL20 in the recurrence group and the non-recurrence group were significantly higher than those in the control group(P<0.01),and the serum TGF-β1,s-CD105 and CCL20 levels in the recurrence group were significantly higher than those in the non-recurrence group(P<0.01).The results of multivariate Logistic regression analysis showed that,age>50 years old,TNM stage III-IV,pathological type of invasive ductal carcinoma,preoperative lymph node metastasis,no postoperative adjuvant therapy,TGF-β1 overexpression,s-CD105 overexpression,and CCL20 overexpression were independent risk factors for postoperative recurrence in triple-negative breast cancer patients(P<0.05).The ROC curve showed that the combined detection of serum TGF-β1,s-CD105,and CCL20 levels had an AUC of 0.879 for predicting postoperative recurrence in triple-negative breast cancer patients,which was higher than that of the three indicators individually.At the same time,the sensitivit

关 键 词：三阴性乳腺癌 转化生长因子-Β1 可溶性CD105 CC趋化因子配体20 复发 

分 类 号：R737.9[医药卫生—肿瘤]