Tapasin蛋白在肿瘤免疫治疗中的应用及前景  

Application and prospect of Tapasin protein in tumor immunotherapy

作　　者：蒋增华 钱雨凡 许阳贤[2] 徐汉辰 JIANG Zenghua;QIAN Yufan;XU Yangxian;XU Hanchen(Institute of Spleen and Stomach Diseases,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Department of Gastrointestinal Surgery,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学中医脾胃病研究所,上海200032 [2]上海中医药大学附属龙华医院胃肠外科,上海200032

出　　处：《上海中医药大学学报》2022年第1期42-48,共7页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家自然科学基金青年基金项目(82104466);上海市科委青年科技启明星计划项目(20QA1409300);上海市高校青年东方学者项目(QD2019034)。

摘　　要：肿瘤免疫是目前恶性肿瘤研究的热点。Tapasin蛋白是一类位于内质网的伴侣分子,其在稳定肽组装复合体、招募主要组织相容性复合体(MHC)Ⅰ类分子、编辑抗原肽等过程中发挥重要作用。研究表明,多种肿瘤细胞通过降低Tapasin蛋白表达影响抗原呈递,进而逃避免疫监视,主要调节途径包括干扰素(IFN)、核因子-κB(NF-κB)信号通路等。Tapasin蛋白与CD8;T细胞、树突状细胞等免疫细胞相互作用,介导肿瘤免疫的发生、发展。对Tapasin蛋白的结构与功能、在肿瘤细胞的表达与调控、与肿瘤免疫的关系等方面的研究进展进行综述,以期为肿瘤免疫治疗及中医药相关研究提供参考。Tumor immunity is the hot spot of malignant tumor research. Tapasin is a kind of chaperone molecules located in the endoplasmic reticulum,which plays an important role in stabilizing peptide assembly complexes,recruiting MHC Ⅰ molecules and editing antigenic peptides. Studies have shown that a variety of tumor cells affect antigen presentation by reducing the expression of Tapasin protein,and then escape immune surveillance. The main regulatory pathways include interferon(IFN)and nuclear factor-κB(NF-κB)signal pathway. Tapasin protein interacts with CD8+T cells,dendritic cells and other immune cells to mediate the occurrence and development of tumor immunity. This paper reviews the research progress on the structure and function of Tapasin protein,its expression and regulation in tumor cells,and its relationship with tumor immunity,so as to provide reference for tumor immunotherapy and related research of traditional Chinese medicine.

关 键 词：Tapasin蛋白 MHC 肿瘤 免疫治疗 

分 类 号：R730.51[医药卫生—肿瘤]