血浆β-TG、PF4和外周血S-100B蛋白在急性脑梗死患者中的表达及临床意义  

Expression and clinical significance of plasmaβ-TG,PF4 and peripheral S-100B in patients with acute cerebral infarction

作　　者：王红丽 汪晶晶 Wang Hongli;Wang Jingjing(Department of Neurology,Shangqiu First People's Hospital,Shangqiu Henan 476000,China)

机构地区：[1]商丘市第一人民医院神经内科,河南商丘476000

出　　处：《保健医学研究与实践》2021年第6期93-99,共7页Health Medicine Research and Practice

基　　金：河南省医学科技攻关项目(LHGJ201914675)。

摘　　要：目的探讨血浆β-血小板球蛋白(β-TG)、血小板第4因子(PF4)和外周血S-100B蛋白在急性脑梗死患者外周血中的表达情况及临床意义。方法选取2016年9月—2018年9月河南省某医院收治的102例急性脑梗死患者为观察组,选取同期在医院健康体检的88位健康人为对照组,比较2组研究对象β-TG、PF4及S-100B蛋白表达水平及观察组患者不同时期β-TG、PF4和外周血S-100B蛋白表达水平,分析β-TG、PF4和外周血S-100B蛋白水平与急性脑梗死患者预后的关系及影响急性脑梗死患者预后的危险因素。结果观察组研究对象β-TG、PF4、S-100B蛋白表达水平均高于对照组,差异均有统计学意义(P<0.05)。脑梗死患者急性期β-TG、PF4、S-100B蛋白表达水平高于恢复期,差异均有统计学意义(P<0.05)。β-TG、PF4及S-100B蛋白高水平表达者中位生存时间均短于低水平表达者,差异均有统计学意义(χ^(2)=7.992、21.160、4.682,均P<0.05)。COX回归分析显示,合并高血压、NIHSS评分高、β-TG高水平、PF4高水平、S-100B蛋白高水平、侧支循环代偿程度不佳是影响急性脑梗死患者预后的危险因素(P<0.05)。结论急性脑梗死患者外周血中β-TG、PF4及S-100B蛋白表达水平明显高于健康人;β-TG、PF4及S-100B蛋白参与血栓形成过程,表达水平越高者预后越差。因此,临床需加强对上述指标的监测。Objective To investigate the expression and clinical significance of plasmaβ-thromboglobulin(β-TG),platelet factor 4(PF4)and peripheral S-100 B in patients with acute cerebral infarction.Methods One hundred and two patients with acute cerebral infarction admitted to a hospital in Henan Province from September 2016 to September 2018 were selected as the observation group,and 88 healthy individuals who had health checkups at the hospital during the same period were selected as the control group.β-TG,PF4 and peripheral S-100 B protein expression levels of the 2 study groups andβ-TG,PF4 and peripheral S-100 B levels of the patients in the observation group at different periods were compared.The relationship betweenβ-TG,PF4 and peripheral S-100 B levels and the prognosis of patients with acute cerebral infarction and the risk factors affecting the prognosis of patients with acute cerebral infarction were analyzed.Resultsβ-TG,PF4 and S-100 B expression levels in the observation group were higher than those in the control group,and the differences were all statistically significant(P<0.05).In the acute phase of cerebral infarction,the expression levels ofβ-TG,PF4 and S-100 B were higher than those in the recovery phase,and the differences were statistically significant(P<0.05).The median survival time of those with high expression levels ofβ-TG,PF4 and S-100 B was shorter than those with low expression levels,and the differences were statistically significant(χ^(2)=7.992,21.160,4.682,all P<0.05).COX regression analysis showed that combined hypertension,high NIHSS score,high level ofβ-TG,high level of PF4,high level of S-100 B,and poor degree of collateral circulation compensation were the risk factors affecting the prognosis of patients with acute cerebral infarction(P<0.05).Conclusion The expression levels ofβ-TG,PF4 and S-100 B in the peripheral blood of patients with acute cerebral infarction were significantly higher than those of healthy subjects.β-TG,PF4 and S-100 B are involved in the process of throm

关 键 词：Β-血小板球蛋白 血小板第4因子 S-100B蛋白 急性脑梗死 表达情况 

分 类 号：R743.33[医药卫生—神经病学与精神病学]