氯胺酮在青少年难治性抑郁症急性期治疗中的研究进展  

Ketamine in the acute treatment of adolescent treatment-resistant depression

作　　者：林珊珊 周燕玲[1] Lin Shanshan;Zhou Yanling(Department of Psychology,the Affiliated Brain Hospital of Guangzhou Medical University,Guangzhou 510370,China)

机构地区：[1]广州医科大学附属脑科医院精神科,510370

出　　处：《神经疾病与精神卫生》2022年第2期118-123,共6页Journal of Neuroscience and Mental Health

基　　金：国家自然科学基金青年项目(81801343);广东省自然科学面上基金项目(2019A1515011366)。

摘　　要：越来越多的研究证实,氯胺酮具有快速强效的抗抑郁作用,但是多数研究是在成年抑郁障碍患者中开展,鲜有在青少年抑郁障碍人群中研究氯胺酮疗效及安全性的报道。文章主要关注氯胺酮对青少年难治性抑郁症(TRD)患者急性期治疗进展,分析氯胺酮治疗青少年TRD的可行性和应用前景,旨在为氯胺酮在青少年TRD患者中的临床应用提供参考。An increasing number of studies have confirmed ketamine can exert a robust and rapid onset of antidepressant effect.Most of the current clinical evidences were from studies in adult patients,while the efficacy and safety of ketamine have not been sufficiently evaluated in adolescent treatment-resistant depression(TRD).The aim of this study was to review the research progress of ketamine in the acute treatment of adolescent TRD,aiming to provide a basis for ketamine’s clinical application in adolescent patients.

关 键 词：氯胺酮 青少年抑郁 抗抑郁 综述 

分 类 号：R749.4[医药卫生—神经病学与精神病学]