PKP2在卵巢上皮性浆液性囊腺癌组织中的表达及临床意义  

The expression and clinical significance of PKP2 in epithelial ovarian serous cystadenocarcinoma tissues

作　　者：李思婷 高玲玲 胡悦欣 勾睿 董晖 刘鸥萱 李潇[1,2] 林蓓 LI Siting;GAO Lingling;HU Yuexin;GOU Rui;DONG Hui;LIU Ouxuan;LI Xiao;LIN Bei(Department of Gynecology and Obstetrics,Shengjing Hospital Affiliated to China Medical University,Liaoning Shenyang 110004,China;Key Laboratory of Maternal Fetal Medicine of Liaoning Province,Key Laboratory of Obstetrics and Gynecology of Higher Education of Liaoning Province,Liaoning Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院妇产科,辽宁沈阳110004 [2]辽宁省母胎医学重点实验室,辽宁省高校妇产科重点实验室,辽宁沈阳110004

出　　处：《现代肿瘤医学》2022年第6期1060-1064,共5页Journal of Modern Oncology

基　　金：辽宁省重点研发指导计划(编号:2019JH8/10300022);盛京自由研究者计划(编号:201804)。

摘　　要：目的:探讨PKP2(Plakophilin 2)在卵巢上皮性浆液性囊腺癌组织中的表达及其与卵巢癌患者临床病理特征和预后的相关性。方法:用免疫组化SP法检测PKP2在卵巢上皮性浆液性囊腺癌(76例)、卵巢上皮性交界性肿瘤(23例)、卵巢上皮性良性肿瘤(15例)和正常卵巢(15例)组织中的表达,分析其与卵巢上皮性浆液性囊腺癌患者临床病理特征及预后的关系。结果:免疫组化提示PKP2主要表达于细胞核、细胞质和细胞膜。PKP2在卵巢上皮性浆液性囊腺癌组织中的阳性表达率为86.84%,明显高于卵巢上皮性交界性肿瘤(43.48%)、卵巢上皮性良性肿瘤(26.67%)及正常卵巢(20.00%)(P均<0.05)。在卵巢上皮性浆液性囊腺癌中,PKP2高表达是影响患者总生存期和预后的独立危险因素(P<0.05),但与FIGO分期、分化程度和淋巴结转移等临床病理特征无明显相关性(P>0.05)。结论:PKP2在卵巢上皮性浆液性囊腺癌组织中表达升高,可能是潜在评价卵巢癌预后的指标。Objective:To investigate the expression of PKP2(Plakophilin 2)in epithelial ovarian serous cystadenocarcinoma tissues,and to analyze its correlation with the clinicopathological features and prognosis of ovarian cancer patients.Methods:Immunohistochemistry was used to detect the expression of PKP2 in tissues of epithelial ovarian serous cystadenocarcinoma(76 cases),tissues of epithelial borderline tumor of ovary(23 cases),tissues of epithelial benign tumor of ovary(15 cases),and normal ovarian tissues(15 cases).Its correlation with clinicopathological features and prognosis of patients with epithelial ovarian serous cystadenocarcinoma was analysed.Results:PKP2 was mainly expressed in nucleus,cytoplasm and membrane.The positive expression rate of PKP2 in epithelial ovarian serous cystadenocarcinoma(86.84%)was significantly higher than that in epithelial borderline tumor of ovary(43.48%),epithelial benign tumor of ovary(26.67%)and normal ovarian tissues(20.00%)(all P<0.05).In epithelial ovarian serous cystadenocarcinoma,PKP2 was an independent risk factor for overall survival and prognosis(P<0.05),but had no significant correlation with FIGO stage,degree of differentiation and lymph node metastasis(P>0.05).Conclusion:The expression of PKP2 is increased in epithelial ovarian serous cystadenocarcinoma tissues,and may be a potential prognostic marker for ovarian cancer.

关 键 词：PKP2 卵巢上皮性浆液性囊腺癌 免疫组织化学 

分 类 号：R737.31[医药卫生—肿瘤]