血清IL-6及IL-10在非霍奇金淋巴瘤患者血清中的表达及临床意义  

Expression and clinical significance of serum IL-6 and IL-10 in patients with non-Hodgkin' s lymphoma

作　　者：沈静[1] 张永超 杨融辉[3] 杨威[1] SHEN Jing;ZHANG Yongchao;YANG Ronghui;YANG Wei(Department of Hematology,Shengjing Hospital of China Medical University,LiaoningShenyang 110004,China;Hematology Laboratory,Shengjing Hospital of China Medical University,LiaoningShenyang 110004,China;Department of Blood Transfusion,China Medical University First Hospital,Liaoning Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院第二血液内科,辽宁沈阳110004 [2]中国医科大学附属盛京医院血液研究室,辽宁沈阳110004 [3]中国医科大学第一附属医院输血科,辽宁沈阳110004

出　　处：《现代肿瘤医学》2022年第6期1076-1079,共4页Journal of Modern Oncology

摘　　要：目的:探讨细胞白介素-6(IL-6)和白介素-10(IL-10)在非霍奇金淋巴瘤(non-Hodgkin's lymphoma,NHL)患者中的表达水平及其与患者临床特征、预后的关系。方法:收集我院2013年06月至2016年06月初治的NHL患者278例,回顾性分析IL-6和IL-10的水平。结果:NHL患者外周血IL-6及IL-10浓度明显高于对照组。IL-6与IL-10在不同临床特征的NHL中进行分析,可发现IL-6与IL-10浓度与性别及年龄无明显相关性,但当疾病分期、IPI评分、CRP、LDH、血清β2微球蛋白升高,出现B症状,骨髓侵犯时,IL-6与IL-10水平明显升高(P<0.001)。根据疗效分组,疗效较好的患者起病初期IL-6与IL-10水平较低,而疗效差的患者起病时IL-6与IL-10水平较高。患者缓解后指标可下降或恢复至正常,如未缓解,IL-6与IL-10指标不变或者升高。结论:NHL患者IL-6与IL-10水平升高是患者临床症状较重及预后较差的预测指标。Objective:To determine the change and clinical significance of IL-6 and IL-10 serum level in non-Hodgkin's lymphoma(NHL)patients and their relationship with clinical features and prognosis.Methods:The medical records of 278 patients between June 2013 and June 2016 for NHL were retrospectively analysed.The serum levels of IL-6 and IL-10 in patients were retrospectively analyzed.Results:The serum levels of IL-6 and IL-10 in NHL patients were significantly higher than those in the control group.According to the different clinical characteristics of the group,it can be seen that the serum levels of IL-6 and IL-10 had no significant correlation with gender and age.However,when there were the high levels of stage,IPI score,CRP,LDH,serumβ2 microglobulin,symptom B and bone marrow invasion,the serum levels of IL-6 and IL-10 were significantly higher in patients(P<0.001).According to the efficacy group,patients with better efficacy had lower levels of IL-6 and IL-10 at the beginning of the disease.While patients with poor efficacy had higher levels of IL-6 and IL-10 at the beginning of the disease.After remission,the indicators can be reduced to normal.The indicators of IL-6 and IL-10 remained unchanged or increase if there was no remission.Conclusion:The increase of IL-6 and IL-10 in patients with NHL is a predictor of severe clinical symptoms and poor prognosis.

关 键 词：IL-6 IL-10 非霍奇金淋巴瘤 

分 类 号：R733.4[医药卫生—肿瘤]