肠易激综合征患者血清中过氧化还原酶1和脑源性神经营养因子与抑郁和焦虑症状的相关性研究  

Study on the correlation of serum peroxidoreductase 1 and brain-derived neurotrophic factor with symptoms of depression and anxiety in patients with irritable bowel syndrome

作　　者：李熠萌[1] 李丹[1] 张平[1] 吴晓颖[1] LI Yi-meng;LI Dan;ZHANG Ping(Department of Gastroenterology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院消化科,上海201203

出　　处：《临床和实验医学杂志》2022年第4期364-367,共4页Journal of Clinical and Experimental Medicine

基　　金：上海市中医药领军人才建设项目学术共同体成员培养(编号:ZY3-RCPY-1-1001);上海市三年行动计划中医药专门人才培养(编号:ZY3-RCPY-3-1049)。

摘　　要：目的探讨肠易激综合征(IBS)患者血清中过氧化还原酶1和脑源性神经营养因子与抑郁和焦虑症状的相关性研究。方法回顾性选择2020年2月至2021年3月上海中医药大学附属曙光医院消化科门诊收治的150例慢性腹泻患者。参考罗马Ⅳ标准将患者分为IBS 80例(IBS组),非IBS 70例(非IBS组);检测并比较两组患者的血清过氧化还原酶1(PRDX1)水平、脑源性神经营养因子(BDNF)水平及抑郁自评量表(SDS)和焦虑自评量表(SAS)的评分情况。结果IBS组患者的血清PRDX1水平为(13.47±4.26)ng/L,高于非IBS组[(8.56±2.21)ng/L],血清BDNF水平为(947.21±131.64)pg/mL,低于非IBS组[(1425.67±136.12)pg/mL],差异均有统计学意义(P<0.05)。IBS组患者的SAS评分、SDS评分均高于非IBS组,差异有统计学意义(P<0.05);IBS患者血清PRDX1、BDNF水平与抑郁和焦虑症状间存在相关性(P<0.05)。采用Pearson进行相关性分析,结果发现,IBS患者PRDX1、BDNF水平与抑郁、焦虑症状呈相关性,与抑郁(r=0.276,P<0.001;r=0.322,P<0.001)、易怒(r=0.314,P<0.001;r=0.367,P<0.009)、惊恐(r=0.256,P<0.005;r=0.247,P<0.001)、焦虑(r=0.229,P<0.011;r=0.342,P<0.012)评分呈正相关。结论IBS患者血清PRDX1高表达及血清BDNF低表达,且与抑郁和焦虑症状存在相关性,PRDX1和BDNF可能成为IBS诊疗过程中的生物标志物和靶点。Objective To investigate the correlation between serum peroxidoreductase 1 and brain-derived neurotrophic factor and symptoms of depression and anxiety in patients with irritable bowel syndrome(IBS).Methods One hundred and fifty patients with chronic diarrhea in the outpatient Department of Gastroenterology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from February 2020 to March 2021 were retrospectively selected;all patients were divided into 80 cases of IBS(IBS group)and 70 cases of non-IBS(non-IBS group);detection of serum peroxidoreductase 1(PRDX1)levels,brain-derived neurotrophic factor(BDNF)levels,self-rating depression scale(SDS)and self-rating anxiety scale(SAS)in patients with intestinal diseases's scoring situation.Results The level of serum PRDX1 in the IBS group was(13.47±4.26)ng/L,which was higher than that in the non-IBS group[(8.56±2.21)ng/L],and the level of serum BDNF was(947.21±131.64)pg/mL,which was lower than that in the non-IBS group[(1425.67±136.12)pg/mL],the differences were statistically significant(P<0.05).There was a correlation between the levels of PRDX1 and BDNF in IBS patients and depression and anxiety symptoms(P<0.05);Pearson conducted a correlation analysis.After the analysis,it was found that the PRDX1 and BDNF concentrations in IBS patients were correlated with depression and anxiety symptoms,and depression(r=0.276,P<0.001;r=0.322,P<0.001),irritability(r=0.314,P<0.001;r=0.367,P<0.009),panic(r=0.256,P<0.005;r=0.247,P<0.001),anxiety(r=0.229,P<0.011;r=0.342,P<0.012)the score was positively correlated.Conclusion The high expression of serum PRDX1 and the low expression of serum BDNF in IBS patients are associated with depression and anxiety symptoms,and may become biomarkers and targets in the diagnosis and treatment of IBS.

关 键 词：肠易激综合征 过氧化还原酶1 脑源性神经营养因子 抑郁 焦虑 

分 类 号：R749[医药卫生—神经病学与精神病学] R574[医药卫生—临床医学]