健脾养正法联合促红素治疗晚期胃癌肿瘤相关性贫血的临床研究  

Clinical observation of tonifying spleen and nourishing qi combined with erythropoietin treatment for advanced gastric cancer associated anemia

作　　者：张微[1] 孙魏 邹玺[1] 胡玥[1] ZHANG Wei;SUN Wei;ZOU Xi;HU Yue(Oncology Department,Jiangsu Province Hospital of Traditional Medicine,Nanjing University of Chinese Medicine,Jiangsu Nanjing 210093,China)

机构地区：[1]南京中医药大学附属江苏省中医院肿瘤科,江苏南京210093

出　　处：《现代肿瘤医学》2022年第5期834-837,共4页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:81973782);江苏省重点研发计划专项资金项目(编号:BE2019771)。

摘　　要：目的:观察健脾养正法联合促红素治疗晚期胃癌肿瘤相关性贫血的临床疗效。方法:选取经病理组织学确诊的44例晚期胃癌患者,随机分为对照组(22例)和实验组(22例)。对照组给予促红素150 IU/kg,皮下注射,每周3次,8周后评价疗效。实验组在促红素治疗基础上,以健脾养正法为理论指导,服用健脾养正消癥方加减。观察两组血液学指标变化及临床症状的改善情况。结果:实验组患者治疗前后红细胞计数、血红蛋白及血细胞比容均明显升高,差异有统计学意义(P<0.05)。反映T细胞免疫功能的指标CD4;/CD8;比值明显升高,差异有统计学意义(P<0.05)。实验组KPS评分好转率、疲乏症状评分改善率、恶心、抑郁、焦虑、困倦、食欲症状的改善情况均优于对照组,差异有统计学意义(P<0.05)。结论:健脾养正法联合促红素对于晚期胃癌肿瘤相关性贫血治疗效果较好,能明显提高患者生活质量,可以作为晚期胃癌肿瘤相关性贫血的有效姑息治疗方法。Objective:To compare the efficacy between tonifying spleen and nourishing qi combined with erythropoietin with erythropoietin for patients with advanced gastric cancer associated anemia.Methods:A total of 44 patients with advanced gastric cancer were divided randomly into two groups.There were 22 patients for erythropoietin group(control group: treated with erythropoietin 150 IU/kg three times a week) and 22 patients for tonifying spleen and nourishing qi combinated erythropoietin group(treatment group: treated with erythropoietin 150 IU/kg three times a week and tonifying spleen and nourishing qi decoction).Both two groups were evaluated after 8 weeks.Results:There was significant difference before and after treatment on RBC,HGB and HCT in the treatment group(P<0.05).Peripheral blood CD4;/CD8;subset in treatment group was significantly higher(P<0.05).The KPS score, fatigue score and sicchasia,melancholian dysphoric, drowsy, orexia were improved significantly in treatment group(P<0. 05).Conclusion:Tonifying spleen and nourishing qi combined with erythropoietin is effective for gastric cancer associated anemia.

关 键 词：晚期胃癌 健脾养正法 肿瘤相关性贫血 促红素 

分 类 号：R735.2[医药卫生—肿瘤]