GC-MS/MS对尿液中18种滥用药物的定性检测  

Qualitative Detection of 18 Abused Drugs in Urine with GC-MS/MS

作　　者：谭洁 陈思伊 梁善范 陆亦在[1] 黄丽[1] 苏颖 TAN Jie;CHEN Si-yi;LIANG Shan-fan;LU Yi-zai;HUANG Li;SU Ying(Physical and Chemical Laboratory,Nanning Center for Disease Control and Prevention,Guangxi Nanning 530023,China)

机构地区：[1]南宁市疾病预防控制中心,广西南宁530023

出　　处：《广州化工》2022年第4期97-99,102,共4页GuangZhou Chemical Industry

基　　金：广西壮族自治区卫生健康委员会自筹科研项目(编号:Z20211241)。

摘　　要：分别在酸、碱性条件下,用有机溶剂将18种滥用药物从尿液中提取,气相色谱质谱法(GC-MS/MS)的MRM模式检测,与对照品比较,以保留时间和离子对相对丰度比进行定性分析,建立了GC-MS/MS同时定性检测人尿液中氯胺酮、美沙酮、哌替啶、可待因、可卡因、巴比妥类、苯丙胺类、苯二氮卓类等18种滥用药物方法。在选定的条件下,能在17 min内快速检测18种滥用药物,检出限在0.06~1.8μg/mL之间。结果表明,该法简单、快速、准确,可用于快速筛查违禁的滥用药物。Eighteen kinds of abused drugs in urine were extracted with organic solvent in the conditions of acidity and alkalinity respectively, and then detected by GC-MS/MS with MRM mode and qualitatively analyzed with the retention times and the ratio of relative abundance ratio of ion pairs compared with standard compounds. A method was established for the simultaneous determination of 18 abused drugs including Ketamine, Methadone, Meperidine, Codeine, Cocaine, and other Barbiturates, Amphetamines, and Benzodiazepines in urine with GC-MS/MS. At the selected chromatographic conditions, 18 kinds of common drugs could get a better separation within 17 min. The lowest detection limit was between 0.06~0.18 μg/mL. This method is simple, rapid, accurate, selective and suitable for fast qualitative detection of abused drugs.

关 键 词：酸、碱性条件 滥用药物 GC-MS/MS MRM模式 

分 类 号：G65[文化科学—教育学]