MDT营养干预对老年贲门癌根治性放化疗患者的疗效、免疫功能的影响  

Effects of MDT nutritional intervention on the efficacy and immune function of elderly patients with radical radiotherapy and chemotherapy for gastric cancer

作　　者：戴科军 刘永萍 黄雪 程菁 方明明 DAI Kejun;LIU Yongping;HUANG Xue;CHENG Jing;FANG Mingming(Department of Radiotherapy,the Third Affiliated Hospital of Soochow University,Jiangsu Province,Changzhou213001,China;Cancer Center,Changzhou Tumor Hospital,Jiangsu Province,Changzhou213001,China)

机构地区：[1]苏州大学附属第三医院放疗科,江苏常州213001 [2]江苏省常州市肿瘤医院肿瘤中心,江苏常州213001

出　　处：《中国医药导报》2022年第5期115-118,共4页China Medical Herald

基　　金：江苏省自然科学基金委面上项目(BK20171290);江苏省常州市卫生健康委员会科技项目(ZD202030)。

摘　　要：目的探讨多学科诊疗模式(MDT)营养干预对老年贲门癌根治性放化疗患者的疗效、免疫功能的影响。方法选择2017年12月至2019年12月苏州大学附属第三医院收治的118例老年贲门癌根治性放化疗患者为研究对象,以随机信封法分为对照组和营养干预组,每组59例。两组患者均行根治性放化疗,其中对照组未进行营养教育指导及系统营养支持,营养干预组采用MDT营养干预,两组均持续干预14周。比较两组患者干预前后营养状况主观评估量表(PG-SGA)分级情况、免疫球蛋白M(IgM)、贝克抑郁量表(BDI)、健康促进生活状况评分(HPLP-Ⅱ)。结果干预前,两组PG-SGA分级比较,差异无统计学意义(P>0.05);干预后,营养干预组的PG-SGA分级优于干预前,且营养干预组优于对照组,差异有统计学意义(P<0.05)。干预前,两组IgM、BDI评分、HPLP-Ⅱ评分比较,差异无统计学意义(P>0.05);干预后,两组IgM、BDI评分均较干预前降低,且营养干预组IgM、BDI评分低于对照组,差异均有统计学意义(P<0.05);干预后,两组HPLP-Ⅱ评分均较干预前升高,且营养干预组高于对照组,差异均有统计学意义(P<0.05)。结论对行根治性放化疗的老年贲门癌患者采用MTD营养干预,可改善患者的营养状况,改善免疫功能,且可改善患者的抑郁情绪及生活质量。Objective To investigate the effects of multidisciplinary team(MDT)nutritional intervention on the efficacy and immune function of elderly patients with radical radiotherapy and chemotherapy for gastric cancer.Methods A total of 118 elderly patients with radical radiotherapy and chemotherapy for gastric cancer admitted to the Third Affiliated Hospital of Soochow University from December 2017 to December 2019 were selected as the research subjects.They were divided into control group and nutritional intervention group by random envelope method,with 59 patients in each group.Both groups received radical radiotherapy and chemotherapy.The control group did not receive nutritional education guidance and systematic nutritional support,while the nutritional intervention group received MDT nutritional intervention,which lasted for 14 weeks in both groups.The patient-generated subjective global assessment(PG-SGA)grading,immunoglobulin M(IgM),Beck depression inventory(BDI)and health promoting lifestyle profile-Ⅱ(HPLP-Ⅱ)were compared between two groups before and after intervention.Results Before intervention,there was no significant difference in PG-SGA grading between the two groups(P>0.05).After intervention,the PG-SGA grading of the nutritional intervention group was better than that of the control group,and the difference was statistically significant(P<0.05).Before intervention,there were no significant differences in IgM,BDI scores and HPLP-Ⅱscores between the two groups(P>0.05).After intervention,IgM and BDI scores of both groups were decreased before intervention,and IgM and BDI scores of nutritional intervention group were lower than those of control group,the differences were statistically significant(P<0.05).After intervention,HPLP-Ⅱscores in both groups were higher than before intervention,and nutritional intervention group was higher than control group,the differences were statistically significant(P<0.05).Conclusion MTD nutritional intervention can improve nutritional status,immune function,depression

关 键 词：多学科诊疗模式 营养干预 老年 贲门癌 免疫功能 营养状况 

分 类 号：R735.2[医药卫生—肿瘤]