鞍区颗粒细胞瘤的诊治分析:附3例报道并文献复习  

Diagnosis and treatment of patients with sellar granulosa cell tumor:report of 3 cases and literature review

作　　者：李鹏涛 王佳玲 王西宪[1] 郝轶弘 禹文勇 云经纬 王华一 张庭荣[1] LI Peng-tao;WANG Jia-ling;WANG Xi-xian;HAO Yi-hong;YU Wen-yong;YUN Jing-wei;WANG Hua-yi;ZHANG Ting-rong(Department of Neurosurgery,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)

机构地区：[1]新疆医科大学第一附属医院神经外科,乌鲁木齐830054

出　　处：《中国临床神经外科杂志》2022年第2期104-106,共3页Chinese Journal of Clinical Neurosurgery

摘　　要：目的探讨鞍区颗粒细胞瘤(GCT)的临床特点、诊断及治疗方法。方法回顾性分析经术后病理检查证实的3例鞍区GCT的临床资料,并结合文献进行分析。结果行扩大翼点入路手术2例,其中肿瘤全切除1例,次全切除1例;行经鼻蝶入路神经内镜手术全切除肿瘤1例。术后症状均改善,术后出现一过性尿崩症1例,垂体功能减退1例。3例术后均未行放化疗,随访18~60个月,未见肿瘤复发或进展。结论鞍区GCT临床少见。对于鞍区和/或鞍上区病变,CT显示比脑组织略高密度影,MRI显示T1等信号、T2等信号或低信号、均匀或欠均匀强化,应考虑鞍区GCT可能,以免误诊,延误治疗。治疗方法优先推荐神经内镜经鼻蝶入路手术,可安全、微创地切除肿瘤。Objective To explore the clinical features,diagnosis and treatment of the patients with sellar granulosa cell tumor(GCT).Methods The clinical data of 3 patients with sellar GCT who were definitely diagnosed by postoperative pathological examination were retrospectively analyzed.The related literatures were reviewed.Results Microsurgery through extended pterional approach was performed on 2 patients,of whom 1 patient received total tumor resection and 1 subtotal.Neuroendoscopic surgery through nasal sphenoid approach was performed on 1 patient who received total tumor resection.Preoperative symptoms were improved after the operation.Transient diabetes insipidus occurred in 1 patients,and hypopituitarism in 1 after the surgery.All the patients did not undergo radiotherapy and chemotherapy.The follow-up(range,18~60 months) showed no tumor recurrence or progression.Conclusions Sellar GCT is extremely rare.For the lesions in the sellar and/or suprasellar region,the GCT should be considered when their CT images show slightly higher densities than cerebral tissues,and theri MRI images show iso-intensity on T1-and T2-weighted images and uniform or non-uniform enhancement.For treatment of sellar GCT,neuroendoscopic transnasal sphenoid surgery is preferentially recommended,which can safely and minimally invasively remove the tumors.

关 键 词：鞍区颗粒细胞瘤 临床特征 显微手术 经鼻蝶入路神经内镜手术 

分 类 号：R739.41[医药卫生—肿瘤] R651.11[医药卫生—临床医学]