Composite Biomaterials Based on Poly(L-Lactic Acid)and Functionalized Cellulose Nanocrystals  

作　　者：Mariia Stepanova Ilia Averianov Olga Solomakha Natalia Zabolotnykh Iosif Gofman Mikhail Serdobintsev Tatiana Vinogradova Viktor Korzhikov-Vlakh Evgenia Korzhikova-Vlakh 

机构地区：[1]Institute of Macromolecular Compounds,Russian Academy of Sciences,St.Petersburg,199004,Russia [2]St.Petersburg Research Institute of Phthisiopulmonology,St.Petersburg,194064,Russia [3]Institute of Chemistry,Saint-Petersburg State University,St.Petersburg,199034,Russia

出　　处：《Journal of Renewable Materials》2020年第4期383-395,共13页可再生材料杂志（英文）

基　　金：funded by the Russian Ministry of Education and Science(state contract no.14.W03.31.0014,MegaGrant).

摘　　要：The biocomposite films were prepared from poly(L-lactic acid)and cellulose nanocrystals.To improve interfacial compatibility of hydrophilic cellulose nanocrystals with hydrophobic matrix polymer as well as to provide the osteoconductive properties,cellulose was functionalized with poly(glutamic acid).The modified cellulose nanocrystals were better distributed and less aggregated within the matrix,which was testified by scanning electron,optical and polarized light microscopy.According to mechanical tests,composites filled with nanocrystals modified with PGlu demonstrated higher values of Young’s modulus,elongation at break and tensile strength.Incubation of composite materials in model buffer solutions for 30 weeks followed with staining of Ca^(2+)deposits with Alizarin Red S assay testified better mineralization of materials containing PGlu-modified cellulose nanocrystals as filler.As the result of in vivo experiment,the developed composite materials showed less level of inflammation in comparison with pure polymer matrix and composites filled with non-functionalized cellulose nanocrystals.

关 键 词：BIOMATERIALS polymer composites biodegradable and biocompatible polymers poly(L-lactic acid) cellulose nanocrystals MODIFICATION 

分 类 号：TB3[一般工业技术—材料科学与工程]