Structural basis of acyl-CoA transport across the peroxisomal membrane by human ABCD1  

作　　者：Rong Wang Yu Qin Xiaochun Li 

机构地区：[1]Department of Molecular Genetics,University of Texas Southwestern Medical Center,Dallas,TX,USA [2]Department of Biophysics,University of Texas Southwestern Medical Center,Dallas,TX,USA

出　　处：《Cell Research》2022年第2期214-217,共4页细胞研究（英文版）

基　　金：We thank Y.Sun and D.Stoddard for assistance in data collection and E.Debler for editing paper.This work was supported by NIH grants P01HL020948,R01GM135343 and Welch Foundation(I-1957)(to X.L.);X.L.is a Damon Runyon-Rachleff Innovator supported by the Damon Runyon Cancer Research Foundation(Grant DRR-53S-19)and a Rita C.and William P.Clements Jr.Scholar in Biomedical Research at UT Southwestern Medical Center.

摘　　要：Dear Editor,ABCD1,a member of the subfamily D of ABC transporters,participates in the transport of various fatty acid-CoA derivatives or very long-chain fatty acids(VLCFA)into the peroxisome and is essential for peroxisomal metabolism and lipid homeostasis.1 Dysfunction of human ABCD1 is associated with neurodegenera-tive diseases,including X-linked adrenoleukodystrophy(X-ALD).

关 键 词：TRANSPORT METABOLISM HOMEOSTASIS 

分 类 号：O62[理学—有机化学]