唾液蛋白作为低龄儿童龋预测标志物的研究进展  

Research progress of salivary proteins as predictive biomarkers for early childhood caries

作　　者：朱锦怡 樊琪 周媛 邹静[1] 黄睿洁 Zhu Jinyi;Fan Qi;Zhou Yuan;Zou Jing;Huang Ruijie(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Dept.of Pediatric Dentistry,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院儿童口腔科,成都610041

出　　处：《国际口腔医学杂志》2022年第2期212-219,共8页International Journal of Stomatology

基　　金：四川省卫生健康科研课题(19PJ074)。

摘　　要：低龄儿童龋(ECC)进展迅速,早期诊断困难,严重影响儿童的身心健康。实现对龋高危儿童的早期预测和预防干预是控制ECC的有效手段。随着蛋白质组学技术的发展,唾液蛋白正展现出用于疾病预测和早期诊断的强大优势。唾液蛋白通过多种天然防御机制调节口腔微生态环境,在ECC的控制中发挥重要作用;其水平高低与宿主龋易感性相关,是潜在的龋风险预测指标。本文总结了包括抗菌肽、糖蛋白、酶、免疫球蛋白在内的各类唾液蛋白影响ECC的作用机制,以及作为生物标志物用于疾病预测的研究进展,并在此基础上对唾液蛋白在ECC风险评估中的应用前景进行展望。The rapid progress of early childhood caries(ECC)and difficulty in early diagnosis have seriously affected the physical and mental health of children.Therefore,early prediction and preventive intervention for children at high risk are effective ways to control the disease.With the development of proteomics technology,salivary proteins are showing strong advantages for disease prediction and early diagnosis.Recent studies have shown that salivary proteins regulate the oral microecological environment through a variety of natural defense mechanisms and play an important role in ECC prevention.Salivary protein levels are associated with the host’s susceptibility to dental caries and are a potential predictor for caries risk.This review summarizes the mechanism of how different salivary proteins,including antimicrobial peptides,glycoproteins,enzymes,and immunoglobulins,influence ECC,as well as the research progress of how salivary proteins are used in disease prediction as biomarkers.On this basis,the application of salivary proteins in ECC risk assessment was prospected.

关 键 词：低龄儿童龋 唾液蛋白 龋病易感性 生物标志物 

分 类 号：R788.1[医药卫生—口腔医学]