继发性淋巴水肿动物模型的研究进展  

Progress in Animal Models of Secondary Lymphedema

作　　者：杨杏 潘兴芳[1,2] 赵天易 赵美丹 李忠正[1,2] YANG Xing;PAN Xingfang;ZHAO Tianyi;ZHAO Meidan;LI Zhongzheng(Experimental Acupuncture Research Center,Tianjin University of Chinese Medicine Tianjin 301617,China;School of Acupuncture and Massage,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]天津中医药大学实验针灸学研究中心,天津301617 [2]天津中医药大学针灸推拿学院,天津301617 [3]中国中医科学院中医临床基础医学研究所,北京100700

出　　处：《实验动物与比较医学》2022年第1期62-67,共6页Laboratory Animal and Comparative Medicine

基　　金：天津市自然科学基金(18JCYBJC94100)。

摘　　要：继发性淋巴水肿(secondary lymphedema,SL)严重影响着癌症患者的生理和社会心理状况。创建合适的动物模型进行基础研究,对研究SL的发病机制和治疗方案至关重要。目前SL的动物模型众多,缺乏统一性,造成机制研究进展缓慢。本文根据SL动物模型的相关研究进展,分析了SL研究中实验动物的种类、造模干预方式等。分析结果显示,啮齿类动物(特别是大鼠)是较为理想的实验动物,通过术前、术后两次放射与手术相结合可制备较为稳定持久的慢性SL模型,并且在日常的科研工作中得以证实。Secondary lymphedema(SL)seriously affects the physiological and psychosocial status of cancer patients.The establishment of appropriate animal models for basic research is crucial to study the pathogenesis and treatment of SL.At present,there are many animal models of SL,but the lack of uniformity results in slow progress of mechanism research.Based on the research progress of SL animal models,this paper analyzes the types of experimental animals and the intervention methods of modeling in SL research.The analysis results showed that rodents(especially rats)are ideal experimental animals,and a stable and durable chronic SL model can be prepared by combining surgery with two times of preoperative and postoperative radiation,which has been confirmed in daily scientific research work.

关 键 词：继发性淋巴水肿 动物模型 放射 手术 

分 类 号：Q95-33[生物学—动物学] R-332[医药卫生]