LncRNA介导Runx2调控骨疾病的研究进展  

Research progress in the regulation of lncRNA in bone diseases via Runx2

作　　者：杨雨轩 李婷婷 张士花 元宇[2] 邹军[1] YANG Yu-Xuan;LI Ting-Ting;ZHANG Shi-Hua;YUAN Yu;ZOU Jun(School of Kinesiology,Shanghai University of Sport,Shanghai 200438,China;School of Kinesiology,Guangzhou Sport University,Guangzhou 510630,China)

机构地区：[1]上海体育学院运动科学学院,上海200438 [2]广州体育学院运动科学学院,广州510630

出　　处：《生命科学》2022年第1期55-61,共7页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(81901430,81871835);上海市运动与代谢健康前沿科学研究基地和上海市人类运动能力开发与保障重点实验室(上海体育学院)(11DZ2261100)。

摘　　要：长链非编码RNA (long nocoding RNA, lncRNA)是转录调控、细胞生长和分化等多种生物过程中的关键调节因子。近年有研究表明,lncRNA能够通过骨代谢中的关键因子或者微小RNA (microRNA,miRNA)广泛参与骨质疏松症和骨肉瘤等骨疾病的调控。Runt相关转录因子2 (runt related transcription factor 2, Runx2)是重要的成骨因子,在骨疾病的发生与发展和维持骨代谢稳定中有着不可或缺的作用。LncRNA能通过Runx2调控骨代谢并参与骨疾病的发病过程,但目前国内仍未有关于lncRNA介导Runx2调控骨疾病的综述报道。因此,该文主要以Runx2与骨代谢为切入点,概述lncRNA在骨疾病中的作用,为骨疾病的靶向治疗提供一定的理论基础。Long nocoding RNA(lncRNA) is emerging as key regulators in multiple biological processes, including cell differentiation and transcriptional regulation. In recent years, studies have shown that lncRNA can widely participate in the regulation of bone diseases such as osteoporosis and osteosarcoma through regulating the key factors in bone metabolism or microRNA(miRNA). Runt related transcription factor 2(Runx2) is an important osteogenic factor, which plays an indispensable role in the occurrence and development of bone diseases. LncRNA can regulate bone metabolism and participate in the pathogenesis of bone diseases by mediating Runx2. But there are few reviews reporting that lncRNA regulates bone diseases via Runx2. Therefore, we summarize here the role of lncRNA in bone diseases from the perspective of Runx2 and bone metabolism, which may help to provide more reliable theoretical basis for the targeted therapy of bone diseases.

关 键 词：长链非编码RNA RUNX2 骨疾病 

分 类 号：R681[医药卫生—骨科学]