Efficacy of a combination of dutasteride, tadalafil, and solifenacin in the treatment of previously unsuccessful patients  

作　　者：Kirill Kosilov Irina Kuzina Vladimir Kuznetsov Olga Barabash Ekaterina Fedorishcheva 

机构地区：[1]Department of Social Sciences,School of Humanities,Far Eastern Federal University,Vladivostok,Primorsky region,Russian Federation [2]Department of Clinical Medicine,School of Medicine,Far Eastern Federal University,Vladivostok,Primorsky region,Russian Federation [3]Department of Public Health,Pacific State Medical University,Vladivostok,Primorsky region,Russian Federation [4]Department of Physical Culture and Health and Sports Work,Vladivostok State University of Economics and Service,Vladivostok,Primorsky region,Russian Federation

出　　处：《Asian Journal of Urology》2022年第1期42-50,共9页亚洲泌尿外科杂志（英文）

摘　　要：Objective To evaluate the efficacy and safety of simultaneous administration of dutasteride,tadalafil and solifenacin in the treatment of benign prostatic hyperplasia(BPH)with overactive bladder symptoms and lower urinary tract obstruction in previously unsuccessfully treated men.Methods Patients in Group A(n=97)received dutasteride 0.5 mg/day,tadalafil 2.5 mg/day,and solifenacin 2.5 mg/day;Group B(n=95)received dutasteride 0.5 mg/day,tadalafil 5 mg/day,and solifenacin 5 mg/day;Group C(n=103)received dutasteride 0.5 mg/day,tadalafil 20 mg/day,and solifenacin 10 mg/day.The functional status of the lower urinary tract was assessed using the International Prostate Symptom Score(I-PSS),Overactive Bladder Questionnaire(OABq),International Index of Erectile Function(IIEF),and Male Sexual Health Questionnaire Ejaculatory Dysfunction(MSHQ-EjD)as well as uroflowmetry.Results The total score of the sexual function remained unchanged in Group B of patients 81.3 points vs.80.2 points(p>0.05)according to MSHQ-EjD,61.4 points vs.51.2 points(p>0.05)according to IIEF data.The total assessment of symptoms of hyperactivity significantly decreased in Group C according to OABq data after the 4th week of the study(17.5 points vs.26.1 points,p<0.05)and remained below the baseline until the end of the study(15.2 points).Conclusions The simultaneous administration of standard doses of dutasteride,solifenacin,and tadalafil for 3 months is safe,effective,and can be recommended for patients with BPH to reduce symptoms of obstruction and hyperactivity of the bladder and maintain sexual function.

关 键 词：Lower urinary tract symptoms Benign prostatic hyperplasia DUTASTERIDE TADALAFIL SOLIFENACIN Sexual function 

分 类 号：R699.3[医药卫生—泌尿科学]