肠黏膜屏障的组成及其与肝损伤关系的研究进展  

Progress on the composition of intestinal mucosal barrier and its relationship with liver injury

作　　者：马茜茗(综述) 刘志峰(审校者)[1] Ma Ximing;Liu Zhifeng(Department of Gastroenterology,Children′s Hospital of Nanjing Medical University,Nanjing 210008,China;Department of Pediatrics,Yixing People′s Hospital,Yixing 214200,China)

机构地区：[1]南京医科大学附属儿童医院消化科,210008 [2]宜兴市人民医院儿科,214200

出　　处：《国际儿科学杂志》2022年第1期44-47,共4页International Journal of Pediatrics

基　　金：国家自然科学基金(81570470)。

摘　　要：健康肠道的完整黏膜屏障是阻止物质易位的防线。目前动物模型和人类病理学研究证明,肠黏膜屏障功能的变化与肝病的发生和治疗有着密切的联系。该文就肠黏膜屏障的组成、其与肝损伤的关系以及潜在治疗靶点作一综述。The complete mucosal barrier of the healthy intestine is the line of defense to prevent the translocation of substances.Many animal models and human pathological studies have proved that the changes of intestinal mucosal barrier function are closely related to the occurrence and treatment of liver disease.This review summarizes the composition of intestinal mucosal barrier,its interaction with liver injury and potential therapeutic targets.

关 键 词：肠黏膜屏障 肝损伤 肠-肝轴 细菌易位 肠道微生物 

分 类 号：R73[医药卫生—肿瘤]