乙酰谷酰胺联合联合胞磷胆碱钠注射液对颅脑损伤术后患者临床研究  

Clinical study of acetylglutamine combined with citicoline injection in patients after craniocerebral injury

作　　者：张辉喜 Zhang Huixi(The First Hospital of Traditional Chinese Medicine,Hunan 415000)

机构地区：[1]湖南常德市第一中医医院,湖南415000

出　　处：《天津药学》2022年第1期23-27,共5页Tianjin Pharmacy

摘　　要：目的:探讨乙酰谷酰胺注射液联合联合胞磷胆碱钠注射液对颅脑损伤术后患者肠道黏膜功能、神经特异性烯醇化酶(NSE)和炎症因子影响。方法:选择本院于2020年1月—2021年6月行开颅减压术治疗颅脑损伤患者68例,运用随机表法分为观察组34例与对照组34例。两组患者入院均行补液、吸氧、监测生命体征及止血等处理,且均行开颅减压术治疗。对照组于术后1 d给予胞磷胆碱钠注射液0.5 g,加入到100 mg的5%葡萄糖注射液中,缓慢滴注,1次/d;观察组在对照组基础上结合乙酰谷酰胺注射液0.6 g,加入到250 ml的5%葡萄糖注射液中静脉滴注,1次/d。两组疗程均为14 d。比较两组治疗前与治疗14 d格拉斯哥昏迷(GCS)评分和急性生理与慢性健康(APACHE Ⅱ)评分、肠道黏膜功能[二胺氧化酶、细菌内毒素和D-乳酸]、NSE和炎症因子[白介素-6(IL-6)、C反应蛋白(CRP)和肿瘤坏死因子-α(TNF-α)]。结果:两组治疗前GCS评分和APACHE Ⅱ评分比较差异无统计学意义(P>0.05);两组治疗后GCS评分高于治疗前,而APACHE Ⅱ评分低于治疗前(P<0.05);观察组治疗后GCS评分高于对照组,而APACHEⅡ评分低于对照组(P<0.05)。两组治疗前血清二胺氧化酶、细菌内毒素和D-乳酸水平比较差异无统计学意义(P>0.05);两组治疗后血清二胺氧化酶、细菌内毒素和D-乳酸水平低于治疗前(P<0.05);观察组治疗后血清二胺氧化酶、细菌内毒素和D-乳酸水平低于对照组(P<0.05)。两组治疗前血清NSE水平比较差异无统计学意义(P>0.05);两组治疗后血清NSE水平低于治疗前(P<0.05);观察组治疗后血清NSE水平低于对照组(P<0.05)。两组治疗前血清IL-6、CRP和TNF-α水平比较差异无统计学意义(P>0.05);两组治疗后血清IL-6、CRP和TNF-α水平低于治疗前(P<0.05);观察组治疗后血清IL-6、CRP和TNF-α水平低于对照组(P<0.05)。结论:乙酰谷酰胺注射液联合联合胞磷胆碱钠注射液对颅脑损伤�Objective:To investigate the effects of acetylglutamine injection combined with citicoline injection on intestinal mucosal function,nerve-specific enolase(NSE),and inflammatory factors in patients after craniocerebral injury.Methods:A total of 68 patients with craniocerebral injury treated by craniotomy decompression in our hospital from January 2020 to June 2021 were selected and divided into the observation group(34 cases)and the control group(34 cases)by random table method.Patients in both groups received fluid infusion,oxygen inhalation,vital signs monitoring and hemostasis,and craniotomy decompression.The control group was given 0.5 g citicoline injection one day after surgery,which was added into 100 mg 5%glucose injection slowly dripped once a day.The observation group was additionally combined with acetylglutamine injection 0.6 g,added into 250 ml 5% glucose injection intravenously,once a day.The treatment course of both groups was 14 days.Glasgow Coma(GCS),acute physiology and chronic health(APACHE Ⅱ)score,intestinal mucosal function[diamine oxidase,bacterial endotoxin,and D-lactic acid],NSE and inflammatory factors[interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α)]were compared between the two groups before and 14 days after treatment.Results:There was no significant difference in GCS score and APACHE Ⅱ score between the two groups before treatment(P>0.05).The GCS scores of the two groups after treatment were higher than those before treatment,while the APACHE Ⅱ scores were lower than those before treatment(P<0.05).After treatment,the GCS score of the observation group was higher than that of the control group,while the APACHE Ⅱ score was lower than that of the control group(P<0.05).There was no significant difference in serum diamine oxidase,bacterial endotoxin,and D-lactic acid levels between the two groups before treatment(P>0.05).The levels of serum diamine oxidase,bacterial endotoxin,and D-lactic acid in both groups after treatment were lower than those befor

关 键 词：乙酰谷酰胺注射液 胞磷胆碱钠注射液 颅脑损伤 肠道黏膜功能 神经特异性烯醇化酶 炎症因子 

分 类 号：R742[医药卫生—神经病学与精神病学]