大剂量阿托伐他汀联合丁苯酞治疗急性脑梗死合并颅内动脉狭窄患者疗效研究  

Study on Efficacy of High-Dose Atorvastatin Combined with Butylphthalide in the Treatment of Acute Cerebral Infarction Complicated with Intracranial Artery Stenosis

作　　者：刘少霓[1] 林楚生[1] 张晓璇 陈浩明 Liu Shaoni(Department of Neurology,Jieyang people's Hospital,Jieyang Guangdong 522000)

机构地区：[1]揭阳市人民医院神经内三科,广东揭阳522000

出　　处：《黑龙江医药》2022年第1期55-57,共3页Heilongjiang Medicine journal

摘　　要：目的:探讨大剂量阿托伐他汀、丁苯酞联合用药在急性脑梗死合并颅内动脉狭窄中治疗效果。方法:选取2018年8月—2021年2月我院收治急性脑梗死合并颅内动脉狭窄患者84例,用随机分组表将患者分为常规组(20mg/d剂量阿托伐他汀、丁苯酞联合治疗,42例)和干预组(40mg/d剂量阿托伐他汀、丁苯酞联合治疗,42例),比较两组患者治疗前后血脂水平、NIHSS评分、颈动脉内膜中层厚度及相关药物不良反应。结果:治疗14天,两组TC、TG、LDL-C水平相对治疗前均下降,但干预组下降程度更显著(P<0.05),两组HDL-C水平相对治疗前升高,但干预组升高程度更显著(P<0.05);治疗14天,干预组NIHSS评分、颈动脉内膜中层厚度低于常规组(P<0.05);两组相关药物不良反应发生率无差异(P>0.05)。结论:大剂量阿托伐他汀、丁苯酞联合用药在急性脑梗死合并颅内动脉狭窄患者中治疗,可显著改善患者神经功能,改善患者颅脑动脉内膜斑块厚度,并不增加药物不良反应发生率,有显著临床疗效和较高治疗安全性。Objective:To explore the therapeutic effect of high-dose atorvastatin and butylphthalide in the treatment of acute cerebral infarction complicated with intracranial artery stenosis.Method:84 patients with acute cerebral infarction complicated with intracranial artery stenosis treated in our hospital from August 2018 to February 2021 were selected.The patients were randomly divided into routine group(20mg/d dose of atorvastatin and butylphthalide combined treatment,42 cases)and intervention group(40mg/d dose of atorvastatin and butylphthalide combined treatment,42 cases).The blood lipid level,NIHSS score and Carotid intima-media thickness and related adverse drug reactions.Result:After 14 days of treatment,the levels of TC,TG and LDL-C in the two groups decreased compared with those before treatment,but the decrease degree in the intervention group was more significant(P<0.05).The level of HDL-C in the two groups increased compared with those before treatment,but the increase degree in the intervention group was more significant(P<0.05);After 14 days of treatment,NIHSS score and carotid intima-media thickness in the intervention group were lower than those in the routine group(P<0.05);There was no difference in the incidence of related adverse drug reactions between the two groups(P>0.05).Conclusion:The combination of high-dose atorvastatin and butylphthalide in the treatment of patients with acute cerebral infarction complicated with intracranial artery stenosis can significantly improve their neurological function,improve the thickness of intracranial artery intimal plaque,and do not increase the incidence of adverse drug reactions.It has significant clinical efficacy and high treatment safety.

关 键 词：急性脑梗死 颅内动脉狭窄 大剂量 阿托伐他汀 神经功能 

分 类 号：R743.33[医药卫生—神经病学与精神病学]