From"step-up"to"step-jump":a leap-forward intervention for infected necrotizing pancreatitis  

作　　者：Dongya Huang Qiang Li Zipeng Lu Kuirong Jiang Junli Wu Wentao Gao Bin Xiao Yi Miao 

机构地区：[1]Department of Pancreas Center,the First Affiliated Hospital with Nanjing Medical University,Nanjing,Jiangsu 210029,China

出　　处：《Chinese Medical Journal》2022年第3期285-287,共3页中华医学杂志（英文版）

基　　金：This work was supported by a grant from the National Natural Sciences Foundation of China(No.81672449)。

摘　　要：Acute pancreatitis(AP)can vary widely in its severity,from being clinically self-limiting to a rapidly fatal course.[1]Necrotizing pancreatitis(NP)is the most serious form and is associated with a poor prognosis;the mortality rate is approximately 15%,or up to 30%for cases of infected necrotizing pancreatitis(INP),which often progresses to sepsis and multiple organ failure,the major cause of death and severe complications.[2]The approach to the management of INP has significantly changed during the last 20 years and continues to evolve with the accumulation of experience,new techniques,and research data.Major surgical intervention and debridement were once the mainstay of therapy for patients with symptomatic necrotic foci,but a minimally invasive approach that focuses on percutaneous and/or endoscopic drainage or debridement is now favored.[2]The"step-up"approach,which involves minimally invasive techniques,represents a new paradigm for the treatment of patients with INP,and open pancreatic debridement is now considered to be the final step in the treatment of NP.[2]

关 键 词：PANCREATITIS INFECTED NECROTIZING 

分 类 号：R576[医药卫生—消化系统]